The traditional Chinese herb Wu-Chu-Yu has been used to treat hypertension for hundreds of years. A previous study indicated that rutaecarpine was the effective component of Wu‑Chu‑Yu, which lowered blood pressure by elevating the expression level of calcitonin gene‑related peptide (CGRP). The present study was performed to investigate the role of transient receptor potential cation channel sub...

Background and objectives: Helicobacter pylori infection is suspected to be associated with extra-gastrointestinal disorders such as diabetes mellitus (DM). It still a subject of investigation whether H. has pathogenic role on DM or diabetic patients have an increased susceptibility infection. The aim the present study was find out rate in individuals without DM.
 Materials methods: conduc...

In polygynous ungulates, males may achieve fertilization through the use of alternative reproductive tactics (ARTs), discrete phenotypic variations evolved to maximize fitness. ARTs are often associated with different male spatial strategies during rut, from territoriality female-following. Although variation in space patterns rutting ungulates is known be largely affected by distribution femal...

Selecting the appropriate tyre configuration and settings for heavy farm vehicles is important to ensure that soil compaction power loss in rolling resistance are minimised traction optimised. This study investigated effect of front-wheel assist (FWA, ≈75 kN) four-wheel drive (4 WD, ≈100 tractors fitted with different configurations (single, dual), sizes inflation pressures on strength (a proxy...

A rutina (RUT) é um flavonóide encontrado em uma ampla variedade de vegetais. Possui múltiplas propriedades terapêuticas, sendo especialmente indicada como venotônico para o tratamento da insuficiência venosa crônica (IVC). Para obtenção medicamentos compostos pela RUT ou associados com outros fármacos necessário avaliar inicialmente a estabilidade do insumo farmacêutico ativo (IFA), fim garant...

BACKGROUND Lignocellulase hypersecretion has been achieved in industrial fungal workhorses such as Trichoderma reesei, but the underlying mechanism associated with this process is not well understood. Although previous comparative genomic studies have revealed that the mutagenic T. reesei strain RUT-C30 harbors hundreds of mutations compared with its parental strain QM6a, how these mutations ac...

BACKGROUND The filamentous fungus Trichoderma reesei is the main industrial cellulolytic enzyme producer. Several strains have been developed in the past using random mutagenesis, and despite impressive performance enhancements, the pressure for low-cost cellulases has stimulated continuous research in the field. In this context, comparative study of the lower and higher producer strains obtain...