The safety and efficacy of combination therapy with 7-ethyl-10-[4-[1-piperidino]-1-piperidino]carbonyloxycamptothecin (CPT-11, irinotecan) and S-1 composed of tegafur, a prodrug of 5-fluorouracil, gimeracil, and potassium oxonate, have been confirmed in patients with colorectal cancer. Previously, we showed that p.o. coadministration of S-1 decreased the plasma concentration of both CPT-11 and ...

the process of the transformation in the ismaili sect and its interal branches can be very helpful in studying ismaili's position taking against its opponents. the climax of the mentioned process coincides with crusades during the eleventh and twelfth centuries. the hostility of shiism against ismaili has an idiological basis, however sunni's general enmity towards ismaili, in additio...

Flexoelectricity, in which a dielectric material develops an electrical polarization response to mechanical strain, is important degree of freedom for designing actuators with simpler structure and higher performance. Its applications are usually limited the nanoscale, though, due phenomenon's inherent size dependence. This study presents $i\phantom{\rule{0}{0ex}}n\phantom{\rule{0}{0ex}}v\phant...

The authors manipulated repetitions and/or changes of abstract response rules and the specific stimulus- response (S-R) associations used under these rules. Experiments 1 and 2, assessing trial-to-trial priming effects, showed that repetition of complete S-R couplings produced only benefits when the rule also repeated (i.e., rule-S-R conjunctions) but costs when identical S-R couplings repeated...

STUDY OBJECTIVE Sgarbossa's rule, proposed for the diagnosis of acute myocardial infarction in the presence of left bundle branch block, has had suboptimal diagnostic utility. We hypothesize that a revised rule, in which the third Sgarbossa component (excessively discordant ST-segment elevation as defined by ≥5 mm of ST-segment elevation in the setting of a negative QRS) is replaced by one defi...

Background: About 50% of heavy elements are produced by the slow neutron capture process ($s$ process) in stars. The element gallium is mostly during weak $s$ massive stars.Purpose: Our activation at ${k}_{\mathrm{B}}T\phantom{\rule{4pt}{0ex}}\ensuremath{\approx}25$ keV first experiment a series and time-of-flight measurements on $^{69}\mathrm{Ga}$ $^{71}\mathrm{Ga}$ relevant for astrophysics.M...