OBJECTIVES The antischistosomal properties of the marketed antiandrogens bicalutamide, flutamide, nilutamide and cyproterone acetate were studied both in vivo and in vitro. METHODS Schistosoma mansoni-infected mice were treated orally with 50-400 mg/kg of the antiandrogens 3 and 7 weeks post-infection. In addition, three drug combinations of nilutamide and praziquantel (200/100, 100/100 and 1...

Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni. Both plant parts were found to...

OBJECTIVES To describe the various factors that come into play when a breast-feeding mother is taking medications, including use of prescription drugs, over-the-counter medications, recreational drugs, galactogogues, and herbal remedies and to provide a framework used for counseling breast-feeding women. SETTING Community and hospital pharmacy and health care settings. PRACTICE DESCRIPTION ...

Cannabis is one of the most popular recreational drugs. The rates of use and dosage, based on the levels of active compounds present in street drugs, is thought to be climbing in the UK and Europe; 40% of 15 years olds in the UK are thought to have tried the drug. There is no dispute that cannabis intoxication can cause brief psychotic episodes or short-term relapse of pre-existing psychotic sy...

Background & Objectives Orphan Drugs (ODs) are medicinal products intended for diagnosis, prevention or treatment of rare diseases. Access to ODs is crucial for patients' health and quality of life. However, patients claim that access to orphan drugs is sometimes restricted, a phenomenon that has grown during the economic crisis. The aim of this study was to identify current problems and future...

Pharmaceutically active compounds (PhACs), including prescription drugs, over-the-counter medications, drugs used in hospitals and veterinary drugs, have been found throughout the water cycle. A desk study was initiated by the Global Water Research Coalition to consolidate a uniform selection of such compounds in order to judge risks of PhACs for the water cycle. By identifying major existing p...

oral health problems, among the most prevalent comorbidities related to addiction, require more attention by both clinicians and policy-makers. our aims were to review oral complications associated with drugs, oral health care in addiction rehabilitation, health services available, and barriers against oral health promotion among addicts. drug abuse is associated with serious oral health proble...

the occurrence of neonatal seizures may be the first and perhaps, the only clinical sign of a central nervous system (cns) disorder in the newborn infant. identifying the etiology for the neonatal seizures is/critical to prognosis and treatment. the most common etiology for neonatal seizures is hypoxic-ischemic encephalopathy. seizures may indicate the presence of a potentially treatable etiolo...

patients and methods in this cross-sectional study, conducted in isfahan and kermanshah medical universities in iran, a total of 425 male medical students were randomly selected with the proportional to size from different faculties to participate voluntarily in the study. a self-report written questionnaire was applied to collect data. then, the obtained data were analyzed by spss version 20 u...