نتایج جستجو برای: schistosomicidal drugs

تعداد نتایج: 224288  

Journal: :iranian journal of public health 0
i. farahmandian f. arfaa sh. keyvan m. sohrabi

in the course of an evaluation of various schistosomicidal drugs in iran, the effect of an organo-phosphorus compound in the-treatment of 45 mild cases of urinary bilhariziasis was assessed and the drug was given in 3 doses of 10 mg/kg body weight each with 3-week intervals. follow-up examinations undertaken 3 weeks after the 1st, 2nd and 3rd doses as well as 3 months after completion of therap...

Journal: :PLoS Neglected Tropical Diseases 2009
Thorsten Meyer Harald Sekljic Stefan Fuchs Heiko Bothe Dieter Schollmeyer Christian Miculka

BACKGROUND Praziquantel (PZQ) is the drug compound of choice in the control and treatment of schistosomiasis. PZQ is administered as a racemate, i. e. 1ratio1 mixture of enantiomers. The schistosomicidal activity arises from one PZQ-enantiomer, whereas the other enantiomer does not contribute to the activity. The WHO's Special Programme for Research and Training in Tropical Diseases (TDR) has a...

2015
Maha Z Rizk Hanan F Aly

Control of schistosomiasis relies on a single drug, praziquantel (PZQ). Given the rising concerns about the potential emergence of PZQ-resistant strains, it has now become necessary to search for novel therapeutics. Efforts have been made for developing new schistosomicidal drugs, or testing existing drugs originally used for non-related diseases. However, the current pace for antischistosomal ...

2014
Arthur Scalzitti Duarte José Clecildo Barreto Bezerra Lourival de Almeida Silva Bruno Junior Neves Carolina Andrade Marina Clare Vinaud Clélia Christina Mello Silva

Background Schistosomiasis remains a severe problem of public health in developing countries [1]. Several reports show that praziquantel, the drug of choice for treating schistosomiasis, can select Schistosoma mansoni strains resistant to the drug. Thus, developing new drugs against this parasitosis is a highly desirable goal [2]. In this context, enzymes involved in energetic metabolism could ...

Journal: :Molecules 2007
Mona A Mahran Samia William Fatem Ramzy Amira M Sembel

A series of benzothiazol-2-yl-dithiocarbamates 3a-d along with their copper complexes 4a-c were synthesized via the reaction of suitable alkyl, aralkyl or heteroaryl halides with the sodium salt of benzothiazol-2-yl-dithiocarbamic acid, followed by complexation with copper sulphate. N-(4-Acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)-N-benzothiazol-2-yl-acetamides 7a-c were synthesized by cyc...

2013
Wael M. Lotfy Aly M. Nageh Neveen A. Hussein Ashraf A. Hassan

The conventional PCR technique was used for studying the schistosomicidal effect of Mirazid® in the murine model. Results of the molecular study were compared with the parasitological results (ova and worm count). The used PCR technique was more sensitive than the Kato-Katz thick smears. Mirazid® showed some schistosomicidal effects against murine Schistosoma mansoni. However, it was not effici...

Journal: :Trends in Applied Sciences Research 2006

Journal: :Pharmaceutical Biology 2001

2015
Bruno J. Neves Rodolpho C. Braga José C. B. Bezerra Pedro V. L. Cravo Carolina H. Andrade

Morbidity and mortality caused by schistosomiasis are serious public health problems in developing countries. Because praziquantel is the only drug in therapeutic use, the risk of drug resistance is a concern. In the search for new schistosomicidal drugs, we performed a target-based chemogenomics screen of a dataset of 2,114 proteins to identify drugs that are approved for clinical use in human...

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