G-protein receptor 84 (GPR84) is an orphan receptor that is induced markedly in monocytes/macrophages and microglia during inflammation, but its pathophysiological function is unknown. Here, we investigate the role of GPR84 in a murine model of traumatic nerve injury. Naive GPR84 knock-out (KO) mice exhibited normal behavioral responses to acute noxious stimuli, but subsequent to partial sciati...

We have generated a SAGE (serial analysis of gene expression) library of normal sciatic nerve and found tags encoding for mRNAs of the complement system highly represented. RNA (RT-PCR and northern blot hybridization) and protein (western blot analysis and immunohistochemistry) studies confirmed these findings. High expression of classical pathway components, alternative pathway components and ...

This study investigated the role and mechanism of aspirin combined with rehabilitation training in nerve injury repair Schwann cell changes rats sciatic injury. Totally, 120 male healthy SD were randomly divided into sham, model, aspirin, + groups, 30 each group. The function index (SFI), photothermal pain tolerance threshold inclined plane test results at 4, 6, 8 weeks after operation compared...

BACKGROUND Nerve injury that produces behavioral changes of allodynia and hyperalgesia in animals is associated with electrophysiologic changes in dorsal root ganglion (DRG) cells. The introduction of drugs into the DRG or the peripheral nerve that alter calcium, sodium, or potassium channel activity may be of therapeutic benefit after nerve injury. For this reason, the authors sought to determ...

We investigated the effect of leg position on the depth of the sciatic nerve and quality of ultrasound images taken at the proximal and mid-thigh level. Twenty-one volunteers with average body mass index were recruited to represent the younger population receiving sciatic nerve blocks for sports injury surgery. The volunteers were placed in the lateral position, with the hip flexed and with the...

Quant Imaging Med Surg 2015;5(6):932-933 www.amepc.org/qims We report a case describing an extraspinal cause of lumbosacral radiculopathy. The goal of this case report is to highlight the contributing role of magnetic resonance imaging (MRI) of peripheral nerves in radicular pain. Axonotmesis of the sciatic nerve could be considered as a post-traumatic piriformis syndrome. A 53-year-old man pre...

Acupuncture has been widely used for pain control. However, the mechanism of pain inhibition by acupuncture is still unclear and evaluation of the physiological effects of acupuncture is limited 1,2) . Many studies have indicated that objective physiological measurements are associated with the determination of the effects of acupuncture. Physiological changes of the acupuncture can be detected...

A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are thought to contribute to the development and maintenance of neuropathic pain. However, mechanisms responsible for neuropathic pain have not been completely delineated. It has been demonstrated that neuropeptide galanin (Gal) is upregulated after injury in the dorsal root ganglion (DRG) and spinal dorsal horn (...

Objective(s): Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice. The aim of this survey was to appraise the effect of lycopene and the ESM nerve guidance channel on scia...