Children with cancer especially acute leukaemia undergo multiple painful procedures like bone marrow biopsy (BM) and lumber puncture (LP) for intrathecal chemotherapy during their first year of treatment. The purpose of this study is to report safety and efficacy of Procedural Sedation and Analgesia (PSA) by paediatric intensivist for oncology procedures in controlled setting in paediatric onco...

Functional magnetic resonance imaging (fMRI) is a unique tool to study brain activity and plasticity changes. Combination of blood-oxygen level-dependent (BOLD) fMRI and electrical forepaw stimulation has been used as a standard model to study the somatosensory pathway and brain rehabilitation in rats. The majority of fMRI studies have been performed in animals anesthetized with alpha-chloralos...

OBJECTIVE To describe the effect of implementing the Joint Commission on Accreditation of Healthcare Organization's guidelines for procedural sedation and analgesia (PSA) on the frequency of adverse events occurring during sedation. DESIGN Prospective, descriptive study. SETTING Urban, tertiary care children's hospital. PARTICIPANTS Patients requiring PSA. INTERVENTIONS A PSA committee ...

PURPOSE We aimed to analyze the effectiveness and safety of low-dose midazolam and ketamine combination for upper gastrointestinal endoscopy (UGIE) in children. METHODS The study included the children (n=425, 10.78±3.81 years) who underwent UGIE for diagnostic purpose during 1 year period. All children were sedated with low dose midazolam (0.1 mg/kg) and ketamine (0.5 mg/kg) intravenously. Ef...

Background The purpose of this study is to investigate the effects of administration order when a sedative drug (midazolam) and an opioid analgesic drug (fentanyl) is applied for moderate intravenous (IV) sedation in dentistry. Methods A retrospective chart review was conducted in one dental clinic during its transition from a midazolam-first to a fentanyl-first protocol for dental procedures...

OBJECTIVE To examine the outcomes of children receiving dexmedetomidine after single-stage airway reconstruction. STUDY DESIGN Historical cohort study. SETTING Tertiary care children's hospital. SUBJECTS AND METHODS Of 61 eligible patients, 50 children undergoing single-stage airway reconstruction were included in the study. Thirty children received dexmedetomidine (Dex) as a primary seda...

CONTEXT Awake craniotomy is increasingly performed the world over. We share our experience of performing craniotomy awake with our anesthetic protocol. AIMS To evaluate and analyze the anesthesia records of the patients who underwent awake craniotomy at our institution. SETTINGS AND DESIGN University teaching hospital, Retrospective study. MATERIALS AND METHODS We reviewed records of the ...

Paediatric sedation has expanded in volume and demand over the past decade. In parallel with the increasing demand for and delivery of sedation by multi-specialty providers, conflicting political agendas have surfaced. With a limited selection of sedatives and few new sedatives to market over the past decade, some providers utilize agents that formerly were considered exclusive for administrati...

introduction: tonsillectomy is the one of the most common types of surgery in children, and is often accompanied by post-operative pain and discomfort. methods of pain control such as use of non-steroidal anti-inflammatory drugs (nsaids), narcotics, and local anesthetics have been used, but each have their own particular side effects. in this study we investigated the effect of ketamine on post...

â  background propofol is used as a sedative drug during colonoscopy. in this study we analyzed the adverse effects of propofol (i.e., hemodyâ­namic and respiratory) on patients who underwent colonoscopies. me t hod s this study was performed in qom province, iran. in this study, 125 patients (63 females, 62 males) were enrolled. study patients were administered (0.5-1.5 mg/kg) intravenous prop...