The intra-subject correlations of three clinically meaningful combinations of serum constituents--(a) potassium, calcium, and albumin; (b) urea, creatinine, and uric acid; and (c) aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase--were studied in 11 healthy men. Duplicate serum samples were obtained at 800 h, 1100 h, and 1400 h on five different days. All assays were p...

Platelets reportedly inhibit lactate dehydrogenase activity in plasma under reaction conditions of low osmolality. We describe observations inconsistent with these reports, and we attribute this "inhibition" to optical interference by platelets during the course of a reaction. We conclude that when platelet lysis is prevented and the optical interference of platelets corrected, platelet-rich pl...

AIM to determine the role of serum lactate and diabetic ketoacidosis (DKA) severity as predictors for five-days mortality in DKA patients. METHODS a prospective cohort study was conducted in DKA patients admitted to emergency department (ED) at Cipto Mangunkusumo Hospital, Jakarta, Indonesia, during 2007-2008 periods. Predictors for 5 days mortality in DKA patients in this study including ser...

The ratio of lactate dehydrogenase (LD-1:LD-2) in serum was studied in 101 patients admitted to a coronary care unit. The clinical reliability of the test could not be predicted from the normality or abnormality of the total serum lactate dehydrogenase (LD) activity. However, for samples with total LD activity below the middle of the normal range, no information was provided by the test. In con...

Muscular ischemia of different duration was induced by use of a tourniquet applied to the rear left leg of rabbits under normothermic or hypothermic conditions, and variations in serum creatine kinase, lactate dehydrogenase, K+, Ca2+, and lactate were determined at various intervals after blood flow was restored. A monocompartmental model analysis applied to the activities of the two enzymes in...

Peripheral Ingestive Signaling Pathways Peripheral Signaling Nagase et al. (1996) compared the effects of exogenous pyruvate and lactate on the activity of hepatic pyruvate dehydrogenase (PDH), pyruvate, lactate, insulin, alanine, and glucose serum levels in O-M rats and S5B/P1 rats. Although the effects were short lived, O-M rats demonstrated higher serum pyruvate and serum lactate levels, but...

INTRODUCTION The objective of this study was to determine the ability of various parameters commonly used for the diagnosis of acute meningitis to differentiate between bacterial and viral meningitis, in adult patients with a negative direct cerebrospinal fluid (CSF) examination. METHODS This was a prospective study, started in 1997, including all patients admitted to the emergency unit with ...

OBJECTIVES We investigated specific lactate thresholds for adverse outcomes in patients presenting to emergency departments (EDs) with suspected sepsis identified based on the performance of a sepsis screening algorithm. DESIGN AND SETTING A standardised sepsis bundle was implemented across public hospitals in New South Wales, Australia, as a quality improvement initiative. A register of all ...

The study was aimed at understanding the nature and pattern of serum lactate, cardiac troponin I changes associated with acute Trypanosoma brucei infection dogs. It also seeks to investigate usefulness these biomarkers in monitoring disease progression predicting mortality. Twenty healthy adult dogs both sexes were used for study. All intra-peritoneally inoculated 1ml phosphate buffered saline ...