Sir, I read with interest the recent article by Jain et al They report a child with two episodes of acute flaccid paralysis occurring at ages two and four years respectively, as a manifestation of serum sickness (related to cefadroxyl administration). However, I would like to make certain observations. Firstly, Jain et al have not presented the details of the nerve conduction studies and theref...

clusion of serum sickness in a subsection of "Delayed hypersensitivity" will unfortunately mislead the student into believing that serum sickness is a type of delayed hypersensitivity reaction, instead of merely an immediate reaction whose onset is delayed by a latent period necessary for sensitization to occur. Two entirely new chapters are offered in the current edition. Immnunological tolera...

BACKGROUND Workplace stressors, such as bullying, are strongly related to subsequent long-term sickness absence, but little is known of the possible physiological mechanisms linking workplace stressors and sickness absence. The primary aim of this study was to investigate to what extent cortisol levels were associated with subsequent sickness absence and if cortisol mediated the association bet...

Rabbits were hyperimmunised systemically over a 4-week period with bovine serum albumin (BSA) in complete Freund's adjuvants and were subsequently challenged systemically with a massive dose of BSA designed to produce serum sickness. Without any ocular manipulation a spontaneous corneal immune reaction was observed which we termed a 'reverse Wessely phenomenon'. It was due to a reversed sequenc...

Few studies have been carried out to examine the relation between postural stability and subjective reports or feelings of motion sickness. Two views seem to exist on the relation between immersion in a virtual reality (VR) environment and subjective feelings of motion sickness. One predicts that the immersion induces both postural instability and motion sickness. Another view is that preimmers...

Complement receptor 1 (CR1) on human erythrocytes (Es) and complement factor H (CFH) on rodent platelets perform immune adherence, which is a function that allows the processing of immune complexes (ICs) bearing C3 by the mononuclear phagocyte system. Similar immune adherence occurs in the glomerular podocyte by CR1 in humans and CFH in rodents. As a model for human IC processing, we studied tr...

BACKGROUND Exposure to shift work has been associated with negative health consequences, although the association between shift work and sickness absence remains unclear. The aim of this study is to investigate associations between cumulative exposure to shift work and sickness absence among ground staff employees of an airline company. METHODS This study used data from the MORE (Monitoring O...

There are emerging ethical issues with regards to the use of animals in the early stages of drug discovery for anti-inflammatory and degenerative diseases from natural products using the activity-directed isolation pathways when many compounds (eg > 100) are present in the crude extract or fraction and are to be tested The above-mentioned is the main reason for proposing the use of the in vitro...

BACKGROUND Natalizumab is a new therapeutic option for relapsing-remitting multiple sclerosis. As with other antibody therapies, hypersensitivity reactions have been observed. In the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) trial, infusion-related hypersensitivity reactions developed in 4% of patients, usually within 2 hours after starting the infusion....

objective: neuroimmune factors contribute on the pathogenesis of sickness behaviors. nigella sativa (ns) has anti-inflammatory, anti-anxiety and anti-depressive effects. in the present study, the effect of ns hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (lps) was investigated. materials and methods: the rats were divided into five groups (n=10 in each): (1) control...