During an extensive arteriographic investigation of subjects with arteriosclerotic, atherosclerotic, and thrombotic cerebral vascular disease, considerable delay has often been observed in opacification of the small cerebral arteries (Meyer, Sheehan, and Bauer, 1960; Sheehan, Bauer, and Meyer, 1960; Bauer, Sheehan, and Meyer, 1961; Bauer, Sheehan, Wechsler, and Meyer, 1962). The delay in fillin...

During an extensive arteriographic investigation of subjects with arteriosclerotic, atherosclerotic, and thrombotic cerebral vascular disease, considerable delay has often been observed in opacification of the small cerebral arteries (Meyer, Sheehan, and Bauer, 1960; Sheehan, Bauer, and Meyer, 1960; Bauer, Sheehan, and Meyer, 1961; Bauer, Sheehan, Wechsler, and Meyer, 1962). The delay in fillin...

The relationship of relapses to long-term disability in multiple sclerosis is uncertain. Relapse reduction is a common therapeutic target but clinical trials have shown dissociation between relapse suppression and disability accumulation. We investigated relationships between relapses and disability progression for outcomes of requiring assistance to walk, being bedridden and dying from multipl...

A síndrome de Sheehan refere-se ao hipopituitarismo secundário a necrose hipofisária devido hipotensão grave precipitada por hemorragia pós parto. Sua apresentação pode ser forma aguda ou crônica, sendo esta última caráter insidioso, com sintomas inespecíficos, levando, frequentemente, um diagnóstico tardio. investigação requer uma história obstétrica compatível parto, evoluindo agalactia e ame...

INTRODUCTION Previously, in a 40-week, randomised, double-blind, placebo-controlled core study comprising three phases (9-week dose confirmation, 5-week open-label dose optimisation and 6-month maintenance of effect) in adults with attention-deficit/hyperactivity disorder (ADHD), methylphenidate modified-release long-acting formulation (MPH-LA) at 40-80 mg/day controlled ADHD symptoms as well a...

  Background: Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The present study aimed to compare hand dexterity of MS patients with low Expanded Disability Status Scale (EDSS) scores and healthy adults. It also sought to identify the predictors of disability status of patients with MS based on their m...