The biochemical influence of flavonolignans from the milk thistle Silybum marianum has been tested on kidney cells of African green monkeys. Two nonmalignant cell lines were selected, with the focus of the work on the fibroblast-like Vero line. Proliferation rate, biosynthesis of protein and DNA, and the activity of the enzyme lactate dehydrogenase (as a measure of the cellular metabolic activi...

The endophytic fungus Penicillium restrictum was isolated from the stems of a milk thistle (Silybum marianum) plant. In culture, the fungus produced distinct red guttates, which have been virtually uninvestigated, particularly from the standpoint of chemistry. Hence, this study examined the chemical mycology of P. restrictum and, in doing so, uncovered a series of both known and new polyhydroxy...

BACKGROUND Silymarin, the main flavonoid constituent element extracted from Silybum marianum possessing antioxidant activity, is already known to be able to block the NF-κB activation process and result in cell apoptosis, implicating silymarin's potential to control cancer cell growth. MATERIALS AND METHODS In this study, based upon the above assumption, silymarin was administered to a highly...

apterous viviparous female of dysaphis inulae sp. n. living on inula britanica and d. lappae cynarae (theobald) living on silybum marianum is described and newly recorded from iran, respectively. the latter aphid species is redescribed and an identification key for the species of dysaphis boerner on asteraceae is also presented.

Silybum marianum is a medicinal plant that produces silybins A and B, which exhibit liver-protective activities. The He–Ne laser pre-sowing seed treatment has been used as physical biostimulator in numerous plants to promote germination, growth, secondary metabolite production. Thus, this study, at 632.8 nm was irradiate S. seeds with the aim of promoting growth well enhancing production silybi...

Silybin (SB), a natural flavonoid isolated from Silybum marianum , has been used to treat hepatic fibrosis in clinical settings and as dietary supplement, because of its hepatoprotective potential. Numerous studies have shown that SB also exerts promising anticancer effects; however, the targets underlying mechanism were unclear. Herein, we found significantly inhibited proliferation non-small ...