Purpose: Src is overexpressed or hyperactivated in a variety of human cancers, including thyroid carcinoma. Src is a central mediator in multiple signaling pathways that are important in oncogenesis and cancer progression. In this study, we evaluated the effects of an Src inhibitor, SKI-606 (bosutinib), in a spontaneous metastatic thyroid cancer model with constitutively activated Src (ThrbPV/P...

Human coronary artery endothelial cells (HCAECs) have the potential to undergo fibrogenic endothelial-mesenchymal transition (EndMT), which results in matrix-producing fibroblasts and thereby contributes to the pathogenesis of cardiac fibrosis. Recently, the profibrotic cytokine transforming growth factor-β (TGF-β) is shown to be the crucial pathogenic driver which has been verified to induce E...

The development of mountain tourism in Greece is a recent phenomenon and one that has been affected by the economic crisis. Key factor to its development was the ski resorts that spread through the country especially in the last twenty years. The present paper focuses on a ski resort in Greece, Elatochori Pierias, attempting to assess the impact of mountain tourism on the sustainable developmen...

Src up-regulation is a common event in human cancers. In colorectal cancer, increased Src levels are an indicator of poor prognosis, and progression to metastatic disease is associated with substantial increases in Src activity. Therefore, we examined the activity of SKI-606, a potent inhibitor of Src and Abl kinases, against colon tumor lines in vitro and in s.c. tumor xenograft models. SKI-60...

Aims: Experience morphology of acceleration signals, extract useful information and classify time periods into defined techniques during cross-country skiing. Method: Three Norwegian cross-country skiers ski skated one lap in the 2011 world championship sprint track as fast as possible with 5 accelerometers attached to their body and equipment. Algorithms for detecting ski/pole hits and leaves ...

Kernel concurrency bugs are notoriously difficult to find during testing since they are only triggered under certain instruction interleavings. Unfortunately, no tools for systematically subjecting kernel code to concurrency tests have been proposed to date. This gap in tool support may be explained by the challenge of controlling precisely which kernel interleavings are executed without modify...

We introduce a new structured kernel interpolation (SKI) framework, which generalises and unifies inducing point methods for scalable Gaussian processes (GPs). SKI methods produce kernel approximations for fast computations through kernel interpolation. The SKI framework clarifies how the quality of an inducing point approach depends on the number of inducing (aka interpolation) points, interpo...

In this paper we identify skier groups in data from RFID ski lift gates entrances. The ski lift gates’ entrances are real-life data covering a 5-year period from the largest Serbian skiing resort with a 32,000 skier per hour ski lift capacity. We utilize three representative algorithms from three most widely used clustering algorithm families (representative-based, hierarchical, and density bas...

MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate growth and differentiation. miRNAs are frequently located at cancer-specific fragile sites in the human genome, such as chromosome 7q. The nuclear oncogene SKI is up-regulated in acute myeloid leukemia (AML) with -7/del7q. Here we asked whether loss of miRNAs on chromosome 7q may explain this up-regulation. miR-29a expression w...

Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it is related with cancer progression and poor prognosis. Here we show that AURKA phosphorylates in vitro the transcripcional co-repressor Ski on aminoacids Ser326 and Ser383. Ph...