The inhibition of the mammalian soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of hypertention and inflammation. The problems of limited water solubility and high melting points commonly displayed by the active 1,3-disubstituted ureas prevent the further development of potent urea-based sEH inhibitors. Therefore, a new class of potent inhibitors of sEH were designed...

The water solubility of salts is ordinarily dictated by lattice energy and ion solvation. However, in the case of low melting salts also known as ionic liquids, lattice energy is immaterial and differences in hydrophobicity largely account for differences in their water solubility. In this contribution, the activity coefficients of ionic liquids in water are split into cation and anion contribu...

The dynamic and energetic properties of the alkali and halide ions were calculated using molecular dynamics (MD) and free energy simulations with various different water and ion force fields including our recently developed water-model-specific ion parameters. The properties calculated were activity coefficients, diffusion coefficients, residence times of atomic pairs, association constants, an...

varying degrees of water solubility. Some additives (e.g., methyl tertiary-butyl ether and alcohols) are highly soluble. Other components (e.g., benzene, toluene, ethylbenzene, and xylenes) are slightly soluble. Many components (e.g., ndodecane and n-heptane) have relatively low water solubility under ideal conditions. Physical and chemical properties which affect transport and fate of selected...

varying degrees of water solubility. Some additives (e.g., methyl tertiary-butyl ether and alcohols) are highly soluble. Other components (e.g., benzene, toluene, ethylbenzene, and xylenes) are slightly soluble. Many components (e.g., ndodecane and n-heptane) have relatively low water solubility under ideal conditions. Physical and chemical properties which affect transport and fate of selected...

Solubility enhancement of meloxicam and rofecoxib, which are poorly soluble in water, was attempted. These are available in the form of solid dosage forms but not in solution dosage forms due to their low aqueous solubility. In this work, aqueous solubility of meloxicam and rofecoxib was improved using the biocompatible solvents such as ethanol, propylene glycol, glycerin, and PEG 400. Physico-...

tant molecular property, playing a large role in the behavior of compounds in many areas of interest. Given the importance of solubility, a means of prediction based solely on molecular structure should prove a useful tool, as many compounds exist for which the solubility simply is not available. The solubility of chemicals and drugs in the water phase has an essential influence on the extent o...

Today, due to the natural decline of oil exploitation, the use of methods of oil recovery, has made significant progress. However, these methods are accompanied by accumulation and deposition of mineral deposits in oil field installations. In the present study, aqueous solutions, strontium sulfate, barium sulfate, manganese sulfate and nickel sulfate are studied, in terms of EUNIQUAC model and ...

This work aims at providing experimental and theoretical information about the water–perfluorocarbon molecular interactions. For that purpose, experimental solubility results for water in cyclic and aromatic perfluorocarbons (PFCs), over the temperature range between (288.15 and 318.15) K, and at atmospheric pressure, were obtained and are presented. From the experimental solubility dependence ...

INTRODUCTION Solubility of mineral trioxide aggregate (MTA) is an important characteristic that affects other properties such as microleakage and biocompatibility. Distilled water (DW) has previously been used for solubility tests. This experimental study compared the solubility of MTA in DW, synthetic tissue fluid (STF) and new simulated plasma (SP). METHODS AND MATERIALS In this study, 36 s...