نتایج جستجو برای: spatial memory
تعداد نتایج: 601705 فیلتر نتایج به سال:
Background & Objective: Post traumatic stress disorder (PTSD) is an anxiety reaction, which occurs as a result of encountering a seriously traumatic event during one’s lifetime. The aim of this study was to evaluate the effect of saffron aqueous extract and crocin on spatial memory and learning with the Barnes maze in a PTSD model on male Wistar rats (Weighting 200–250 gr). Materials & Method...
Background and objective: Insulin and its receptor are located in the central nervous system where it regulates many important processes such as neural proliferation, apoptosis, synaptic transmission, neuronal survival, synaptic plasticity, learning and memory. Alzheimer's disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) plaques, and intracellular aggregation of...
background: sporadic alzheimer’s disease (sad) is caused by genetic risk factors, aging and oxidative stresses. the herbal extract of rosa canina (r. canina), tanacetum vulgare (t. vulgare) and urtica dioica (u. dioica) has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. in this study, the neuroprotective effects of this herbal extract in the rat model of sad was i...
objective(s) we determined the effect of a high fructose diet either alone or in combination with iranian shallot or garlic extract on cognitive functions, plasma lipid profile, and the intraperitoneal glucose tolerance test (ipgtt). materials and methods following induction of insulin resistance in fructose-fed rats (fru-fed), they were randomly assigned to three subgroups. the first subgroup ...
Background and Objective: Alzheimer’s disease is a prevalent central nervous system disease with no definitive treatment till now. So, in the present study the effect of an important herbal medicine, withania somnifera (Ws), was investigated on progression of Alzheimer’s disease. Materials and Methods: We used intracerebroventricular streptozotocin (STZ) injection as a model for Alz...
Introduction: The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ) -induced memory impairment. Methods: Twenty-eight Wistar male rats received intrahipp...
Background and Objective: Temporal lobe epilepsy (TLE) usually leads to memory deficit. In this study, we tried to assess the effect of Withania somnifera extract on the impaired learning and memory in the intrahippocampal kainate model of TLE in the rat. Materials & Methods: Male rats (n=32) were divided into sham, extract+sham, kainite, and kainite+extract. For induction of epilepsy, unilate...
Introduction: Cognitive dysfunction is recognized as a significant feature of multiple sclerosis (MS). Oxidative stress plays an important role in the pathogenesis of MS. Toxic demyelination by ethidium bromide (EB) is one of the common methods for induction of MS, which leads to neuronal death by production of free radicals and enhancement of oxidative stress burden. According to previous p...
In order to gain insight into the nature of human spatial representations, the current study examined how those representations are affected by blind rotation. Evidence was sought that while certain environmental aspects may be updated independently of one another, other aspects may be grouped (or chunked) together and updated as a unit. Participants learned the locations of an array of objects...
Navigating through a remembered space depends critically on the ability to stay oriented with respect to the remembered environment and to reorient after becoming lost. This chapter describes the roles of long-term spatial memory, sensorimotor spatial memory, and path integration in determining spatial orientation. Experiments presented here highlight the reference direction structure of long-t...
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