PURPOSE To assess the effectiveness of sympathetic skin response in evaluating peripheral sympathetic nerve activity of patients with spinal cord injury, and to report on the basic properties of sympathetic skin response. METHODS Sympathetic skin response evoked by electrical stimulation was recorded from the palms and soles of healthy volunteers and patients with spinal cord injury. RESULT...

Traumatic injury to the central nervous system results in the disruption of the blood brain/spinal barrier, followed by the invasion of cells and other components of the immune system that can aggravate injury and affect subsequent repair and regeneration. Although studies of chronic neuroinflammation in the injured spinal cord of animals are clinically relevant to most patients living with tra...

Spinal cord injury is devastating injury, which has serious impact not only to the individual but also to family members, society and the nations as a whole because the available treatment options are expensive, prolong, resource consuming and do not always fulfill the expectation of patient and family members. Worldwide incidence of spinal cord injury has been reported up to 236-1009/million/y...

A spinal cord injury (SCI) refers to any injury to the spinal cord that is caused by trauma instead of disease. Depending on where the spinal cord and nerve roots are damaged, the symptoms can vary widely, from pain to paralysis to incontinence. Spinal cord injuries are described at various levels of "incomplete", which can vary from having no effect on the patient to a "complete" injury which ...

the overall goal of this study was to identify the appropriate biomaterials able to facilitate the regeneration in rat's injured adult spinal cord. acute damage to axons is manifested as a breach in their membranes, ionexchange distortion across the compromised region, local depolarization and even conduction block. it would be of particular importance to interrupt the progress of events h...

background: spinal cord injury (sci) stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. the purpose of this study was to determine the anti-inflammatory effects of epigallocatechin gallate (egcg) on traumatized spinal cord. methods: rats were randomly divided into four groups of 12 rats each as follow: sham-operated group, trauma group...

results the results showed that bbb test showed an improvement in the cr, while the quantitative analysis showed that the improvement rate was higher in the rats treated with cnl than those treated with bmscs only or the untreated animals, similar results were noticed in the improvement index. immunohistochemical analysis of the tissue section prepared from the cr showed that the transplanted c...

Top ten research priorities for spinal cord injury # Priority question 1 Does activity based rehabilitation, including functional electrical stimulation coupled with physical activity and hydrotherapy, improve outcomes such as muscle function and neuroplasticity after spinal cord injury? 2 Does stem cell therapy result in better outcomes after spinal cord injury and does this depend on the type...

Objective(s):Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injectio...