Differentiation-inducing factor-1 [1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (DIF-1)] is an important regulator of cell differentiation and chemotaxis in the development of the cellular slime mold Dictyostelium discoideum However, the entire signaling pathways downstream of DIF-1 remain to be elucidated. To characterize DIF-1 and its potential receptor(s), we synthesized two flu...

This paper investigates how change in population size affects the reliability of the likelihood ratio (LR)-based forensic speaker classification. Using features of the long term F0 distribution, we performed LR-based speaker classification and examined its performance with population sizes from 10 to 120. The results revealed that LRs could be heavily influenced by the population data. We disco...

Background. Depression is one of the major public health concerns among older adults. Participation in preferred leisure activities has been found to be effective for reducing the symptoms of depression among this population. Objectives. The purpose of this study was to conduct a meta-analysis of the association between leisure participation and depression. Methods. A systematic review of Pub...

BACKGROUND Fairness is a critical component of defensible assessment. Candidates should perform according to ability without influence from background characteristics such as ethnicity or sex. However, performance differs by candidate background in many assessment environments. Many potential causes of such differences exist, and examinations must be routinely analysed to ensure they do not pre...

There are four tests--the likelihood ratio (LR) test, Wald's test, the score test and the exact test--commonly employed in genetic association studies. On comparison of the four tests, we found that Wald's test, popular in genome-wide screens due to its low computational demands, exhibited a paradoxical behaviour in that the test statistic decreased as the effect size of the variant increased, ...

Lignin can be used as a cheap natural raw material to prepare organic aerogels based upon gelation and supercritical drying in ethanol. The aerogels were prepared from a mixture of the raw materials with lignin (L), resorcinol (R), and formaldehyde (F), followed by a reaction catalyzed by NaOH(C). The effect of the preparation conditions, such as the LRF concentration, the mass ratio of LR to N...

In this paper, we consider two tradeo results regarding the economy of description in parsing. One result is on the tradeo between the size of a parser and its ability to detect an error early. The other result is on the tradeo between the size of an LR(k)-grammar and the length k of the lookahead. c © 2000 Elsevier Science B.V. All rights reserved.

PURPOSE Merkel cell carcinoma (MCC) is a rare and often aggressive skin cancer. Typically, surgery is the primary treatment. Postoperative radiation therapy (PORT) is often recommended to improve local control. It is unclear whether PORT is indicated in patients with favorable Stage IA head and neck (HN) MCC. METHODS AND MATERIALS We conducted a retrospective analysis of 46 low-risk HN MCC ca...

With recent advances in biotechnology, genome-wide association study (GWAS) has been widely used to identify genetic variants that underlie human complex diseases and traits. In case-control GWAS, typical statistical strategy is traditional logistical regression (LR) based on single-locus analysis. However, such a single-locus analysis leads to the well-known multiplicity problem, with a risk o...