Cell competition is a quality control mechanism that eliminates unfit cells. How cells compete is poorly understood, but it is generally accepted that molecular exchange between cells signals elimination of unfit cells. Here we report an orthogonal mechanism of cell competition, whereby cells compete through mechanical insults. We show that MDCK cells silenced for the polarity gene scribble (sc...

We present a general mathematical theory for the mechanical interplay in tissue-equivalents (cell-populated collagen gels): Cell traction leads to compaction of the fibrillar collagen network, which for certain conditions such as a mechanical constraint or inhomogeneous cell distribution, can result in inhomogeneous compaction and consequently fibril alignment, leading to cell contact guidance,...

Operating systems for sensor networks must provide energy and memory-space efficient execution environments for applications because of the resource constraints of the sensor nodes. The shared-stack cooperative threads have been proposed to conserve stack memory-space and to minimize the possibility of stack overflow in the sensor operating systems. However, stack switching brings about externa...

Dynamic compaction is a soil improvement method which has been widely used for the increase of bearing capacity through stress wave propagation during heavy tamping. The cost and time of project implementation can be effectively curtailed by developing a model that can be used in the design of dynamic compaction operations. The numerical models offered so far are mostly one or two-dimensional, ...

Soil compaction forms a major threat to the well-functioning of agricultural soils. This is primarily driven by increasing wheel loads modern farming machinery and increased frequency field operations in periods when soil moist wet thus more prone compaction. The application slurry early spring can have highly detrimental impact, certainly for crop like sugar beet, which sensitive A one-year ex...

The impact of the Degree Saturation (DOS) on granular Sub Base material was investigated in this study. Seven numbers CBR (California Bearing Ratio) samples were fabricated at 95% compaction according to Standard Australian, AS 1289.6.1.1. These prepared against targeted moisture variation between DOS 50% and 70%. In particular, laboratory through proper gradation with optimum content (OMC) app...

The paper considers the Baer-Nunziato model for two-phase flow in porous media, with discontinuous porosity. Computing solutions of the Riemann problem rests on capturing the jump in the solution across the porosity jump. A recent study [8] showed that numerical discretizations may fail to correctly capture the jump conditions across the so-called compaction wave, and yield incorrect solutions....

Technique for Order preference by Similarity to Ideal Solution (TOPSIS) is a Multi Attribute DecisionMaking (MADM) technique employed in diverse disciplines for the prioritization of alternative options/solutions to a problem. Test vector compaction for analog fault detection is a field which is witnessing continuous growth and experimentation. This study suggests a novel TOPSIS-based approach ...

Purpose: As in-line process analytics are becoming more widely accepted, it is important to illustrate that a measurement of interest will provide the expected outcome if that control point has reached a desired level. This methodology is especially true for novel applications. The purpose of this work was to investigate the role of densification during high shear granulation and the resulting ...

Genomic DNA is organized three-dimensionally in the nucleus, and is thought to form compact chromatin domains. Although chromatin compaction is known to be essential for mitosis, whether it confers other advantages, particularly in interphase cells, remains unknown. Here, we report that chromatin compaction protects genomic DNA from radiation damage. Using a newly developed solid-phase system, ...