A neuploidy is a hallmark of cancer, but the path from mutation to extra chromosomes is unclear. Now, Caldwell et al. help fi ll this gap, showing that a cancer-causing mutation promotes chromosome doubling by unfastening the mitotic spindle and hindering cell division. The genome of a cancer cell is a mess, with breaks, rearrangements, and super-fl uous chromosomes. Many researchers speculate ...

The need for palliative care for patients with end-stage renal disease (ESRD) is increasingly recognized. Patients starting renal replacement therapy are now elderly, with a median age of 65 years, and with multiple comorbid conditions. Quality of life is often poor and with advance care planning, patients can be enabled to make the choice of stopping or not starting dialysis. With planned end-...

In low ambient temperatures the engine will have poor output torque and power generation at the first cycles of its performance, long start time and huge noxious emissions because of insufficient temperature and quality of air-fuel mixture and failure of flame to burn the charge. It is noted that any attempt to increase the charge temperature leads to better combustion conditions. By applying t...

This study takes a starting point in what drivers do to avoid drowsiness while driving instead of starting with what researchers know is efficient (Take a short nap). It is concluded that research is missing when it comes to how efficient common behavior countermeasures are and that there is a mismatch between research and how people actually behave. A three stage approach which includes identi...

Multicomponent-distillation calculation methods are classified as rating or design methods. A few rating methods are widely used but none of the design methods has found general acceptance. Recently, a few design methods have been proposed using the stage-tostage calculations and starting from one of the ends of the column, but they require tedious calculations. We present here a simple design ...