BACKGROUND AND PURPOSE The age adjustment of stroke mortality rates may obscure the impact of population changes on the total burden of disease. Deaths from ischemic stroke may rise unless future declines in stroke death rates offset the projected growth in high-risk populations. METHODS Using data on ischemic stroke mortality from the National Center of Health Statistics for 1979 to 1998, we...

Post-stroke infections are common complications in acute stroke patients and are associated with an unfavorable functional outcome. However, reports on the effects of prophylactic antibiotics treatment on post-stroke infections are conflicting, especially those on post-stroke pneumonia and outcomes. We searched the PubMed, Embase, and Web of Knowledge databases up through March 11th, 2016. Seve...

Stroke is the third-leading cause of death in the United States, Canada, Europe, and Japan. According to American Heart Association statistics, there are now 795 000 new strokes each year, resulting in 200 000 deaths, or 1 of every 16 deaths, per year in the United States.1 Ischemic stroke represents 80% of the total, and hemorrhagic stroke makes up the remainder. Stroke is the leading cause of...

BACKGROUND AND PURPOSE In a murine model of stroke, we identified a population of very small embryonic-like (VSEL) stem cells (SCs) in adult murine bone marrow that could be mobilized into peripheral blood (PB). This raised the question of whether a similar population of cells is mobilized in human stroke patients. METHODS We evaluated a number of cells that corresponded to VSEL SCs in the PB...

BACKGROUND Few studies simultaneously investigated lipids and lipoprotein biomarkers as predictors of ischemic stroke. The value of these biomarkers as independent predictors of ischemic stroke remains controversial. METHODS We conducted a prospective nested case-control study among postmenopausal women from the Women's Health Initiative Observational Study to assess the relationship between ...

BACKGROUND AND PURPOSE Understanding on distinct subsets of endothelial progenitor cells may provide insights of endothelial dysfunction or repair in the acute ischemic event. Recent in vitro data have reported the colony-forming unit (CFU) and outgrowth cell population as a subset of endothelial progenitor cells. In this study, we undertook to validate the significance of CFU number and outgro...

I nterest in abnormal breathing after stroke has a long history dating back at least to the observations of John Cheyne in 1818. In recent years this interest has been reawakened by a number of publications on the relations between sleep disordered breathing (SDB) and stroke. These studies have been of two main types—those investigating the possible increased risk of stroke in individuals with ...

The United States has seen the relative rate of stroke death fall by 35.8% and the actual number of stroke deaths decline by 22.8% from 2000 to 2010, primarily due to reduced stroke incidence and lower case fatality rates [1]. Despite substantial progress in acute stroke care over the last few decades, stroke continues to be the leading cause of long-term disability in the United States [2]. Th...