نتایج جستجو برای: structurally mediated model

تعداد نتایج: 2480648  

Journal: :Cell reports 2012
Justin W Chartron David G VanderVelde William M Clemons

In the cytoplasm, the correct delivery of membrane proteins is an essential and highly regulated process. The posttranslational targeting of the important tail-anchor membrane (TA) proteins has recently been under intense investigation. A specialized pathway, called the guided entry of TA proteins (GET) pathway in yeast and the transmembrane domain recognition complex (TRC) pathway in vertebrat...

2013
E. Vance Wilson Soussan Djamasbi

Computer-mediated communication (CMC), such as email, instant messaging, and online texting, is an important channel for influencing message receivers’ behavior. We observe that, while most communication media are structurally biased to support either interpersonal or broadcast modes of communication CMC can support both. We argue in this paper that people respond to this ambiguity by categoriz...

Journal: :Journal of magnetic resonance 2011
Mykhailo Azarkh Oliver Okle Philipp Eyring Daniel R Dietrich Malte Drescher

Spin-label electron paramagnetic resonance (SL-EPR) spectroscopy has become a powerful and useful tool for studying structure and dynamics of biomacromolecules. However, utilizing these methods at physiological temperatures for in-cell studies is hampered by reduction of the nitroxide spin labels and thus short half-lives in the cellular environment. Consequently, reduction kinetics of two stru...

ژورنال: اعتیاد پژوهی 2021

Objective: The aim of this study was to design and test a model of familial (family communication pattern including conversation orientation and conformity orientation, family conflicts and parental religiosity) and individual (self-esteem, self-efficacy and resilience) factors of substance use tendency in students of University of Mohaghegh Ardabili. Method: The present study was descriptive-c...

Journal: :ACS chemical biology 2015
Jörg Robin Jens Brauer Stefan Sulmann Valerio Marino Daniele Dell'Orco Christoph Lienau Karl-Wilhelm Koch

Shaping the temporal response of photoreceptors is facilitated by a well-balanced second messenger cascade, in which two neuronal Ca(2+)-sensor proteins operate in a sequential relay mechanism. Although they share structurally similar sensing units, they differentially activate the same target protein. Here, as a prototypical case in Ca(2+)-mediated signal processing, we investigate differentia...

Journal: :Cancer research 2003
Benjamin Deneen Habib Hamidi Christopher T Denny

The EWS/ETS fusion proteins associated with Ewings family tumors (EFTs) are thought to promote oncogenesis by acting as aberrant transcription factors. Uridine phosphorylase is a gene that is up-regulated by structurally distinct EWS/ETS fusions. Ectopic expression of uridine phosphorylase was able to support anchorage-independent cell growth, indicating that it plays an active role in the onco...

Journal: :Cell 1995
Nicole Schreiber-Agus Lynda Chin Ken Chen Richard Torres Govinda Rao Peter Guida Arthur I Skoultchi Ronald A DePinho

Documented interactions among members of the Myc superfamily support a yin-yang model for the regulation of Myc-responsive genes in which transactivation-competent Myc-Max heterodimers are opposed by repressive Mxi1-Max or Mad-Max complexes. Analysis of mouse mxi1 has led to the identification of two mxi1 transcript forms possessing open reading frames that differ in their capacity to encode a ...

2009
Andrei Malashevich David Vanderbilt

The electronic contribution to the magnetically induced polarization in orthorhombic TbMnO3 is studied from first principles. We compare the cases in which the spin cycloid, which induces the electric polarization via the spin-orbit interaction, is in either the b-c or a-b plane. We find that the electronic contribution is negligible in the first case, but much larger, and comparable to the lat...

2013
ALAA REFAAT SHERIF ABDELHAMED HIDEO YAGITA HIROKI INOUE SATORU YOKOYAMA YOSHIHIRO HAYAKAWA IKUO SAIKI

Berberine (BBR) has been used for the treatment of bacterial and fungal infections and also for cancer-associated symptoms such as diarrhea. Furthermore, it has been reported that BBR may have direct antitumor effects. Although evidence supports the theory that tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising candidate for treating cancer, its usage may be li...

Journal: :The Journal of Experimental Medicine 1996
T Q Cai S D Wright

Integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) mediates the transient adhesion of polymorphonuclear leukocytes (PMN) to surfaces coated with fibrinogen, C3bi, ICAM-1, and other ligands. Recent studies (Cai, T.-Q., and S.D. Wright 1995. J. Biol. Chem. 270:14358) suggest that adhesion may be favored by stimulus-dependent changes in the kinetics of ligand binding by CR3. Cell detachment, on the ...

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