Renal infection rarely occurs following the intravenous injection of Gramnegative bacilli into normal animals. If, however, the kidney has been damaged by either direct trauma or ureteral ligation, an increased susceptibility to infection can be demonstrated."' In this regard, studies have shown that the location of the site of injury within the kidney is important in determining alterations of...

Submit Manuscript | http://medcraveonline.com infectious diseases [1-7]. These drugs were the first efficient treatment to be employed systematically for the prevention and cure of bacterial infections [8-11]. One of the first sulfonamides identified by Domagk et al. [8,9] was the red azo dye known as Prontosil [8,9]. It was active against streptococcal infection in vivo. There have been many a...

The presence of sulfonamide (SA) residues in foods is largely due to the raising of animals with sulfonamide antibiotics added or polluted feedstuff. In this paper, a sensitive method was developed for the determination of the residues of three sulfonamides in animal-derived food; the SAs include sulfadimidine (SDD), sulfadiazine (SDZ), and sulfathiazole (STZ). The method is based on capillary ...

BACKGROUND Structural systematics is the comparison of sets of chemically related crystal structures with the aim to establish and describe relevant similarities and relationships. An important topic in this context is the comparison of hydrogen-bonded structures (HBSs) and their representation by suitable descriptors. RESULTS Three different description methods for HBSs are proposed, a graph...

Sulfa drugs are potent and important anti-pneumocystis agents, but have a high incidence of adverse effects in AIDS patients. Although 15,000 sulfa drugs have been synthesized and dozens have been used in people, relatively few have been tested against P. carinii. In order to determine whether there are sulfa drugs which are better antipneumocystis agents than sulfamethoxazole and dapsone, we h...