Synergy between sulphadiazine and trimethoprim against Escherichia coli has been demonstrated in culture media not containing lysed horse blood despite the presence of pus or a pus extract which inhibited the action of each drug separately. Synergy may therefore be important where pus is present in vivo.

THE following case is reported because of the rarity of this complication with the multiple sulphonamide preparations. The patient, a well-nourished muscular male of 54 years, was admitted on the 8th June 1950 to the Belfast City Hospital with the folloxving history. He had been treated b) his outside doctor for a respiratory infection with "sulphatriad." TIreatment was beguun oni 31/5/50 with ...

Thirty seven N-(5-methoxyphenyl)-4-methoxybenzenesulphonamide with methoxy or/and bromo substitutions (series 1-4) and different substituents on the sulphonamide nitrogen have been synthesised. 21 showed sub-micromolar cytotoxicity against HeLa HT-29 human tumour cell lines, were particularly effective MCF7. The most potent series has 2,5-dimethoxyanilines, especially 4-brominated compounds 23–...

gations: chest x-ray normal; Hb 55%; W.B.C. 7,100 with normal diffierential; iron deficiency on the blood film; E.S.R. 138 mm. in one hour; Paul-Bunnell test negative. Blood culture revealed Haemophilus influenzae type B sensitive to all the usual antibiotics except sulphonamide. This child was treated with ampicillin and made a good recovery. My point in recording this case history is to empha...

We found a small but significant increase in methaemoglobin concentration in 1-6 year old children after routine administration of 5 g of prilocainelignocaine cream before surgery. Although the peak methaemoglobin concentration observed was well within safe limits, the finding of an increased concentration 24 hours after administration suggests that cumulative effects may occur in children rece...

Thiocyanate Ion, Chloramine-T Kinetics of oxidation of potassium thiocyanate by the oxidant chloramine-T (CAT) in presence of NaOH has been studied at 30 °C. At low substrate concentrations, the approximate rate law is, — d[CAT]/dt = k[CAT][KNCS]/[NaOH]2. At higher substrate concentrations, the rate law simplifies to, —d[CAT]/dt = k[CAT]/[NaOH]. Ionic strength and addition of p-toluene sulphona...