BACKGROUND Urinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease. The role of urinary albumin measurements has focused attention on the clinical need for accurate and clearly reported results. The National Kidney Disease Education Program and the IFCC convened a conference to assess the current state ...

surface-enhanced raman spectroscopy (sers) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. this technique consists of locating the target analyte on nanometer range of roughed au-nanoparticles. the presence of the metal nanoparticles provides a tremendous enhancement to the result...

A surrogate constraint is an inequality implied by the constraints of an integ~r program, and designed to capture useful information that cannot be extra~ted from the parent constraints individually but is nevertheless a consequepce of their conjunction. The use of such constraints as originally propo~ed by the author has recently been extended in an important way by EGON! BALAS and ARTHUR GEOF...

In this paper, a highly sensitive graphene-based multiple-layer (BK7/Au/PtSe2/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of novel Coronavirus (COVID-19). The sensor was modeled on basis total internal reflection (TIR) technique real-time ligand-analyte immobilization in sensing region. refractive index (RI) region changed due to interaction di...

Surface-enhanced Raman spectroscopy (SERS) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. This technique consists of locating the target analyte on nanometer range of roughed Au-nanoparticles. The presence of the metal nanoparticles provides a tremendous enhancement to the result...

Plasma transthyretin (TTR) is a plasma protein secreted by the liver that circulates bound to retinol-binding protein 4 (RBP4) and its retinol ligand. TTR is the sole plasma protein that reveals from birth to old age evolutionary patterns that are closely superimposable to those of lean body mass (LBM) and thus works as the best surrogate analyte of LBM. Any alteration in energy-to-protein bala...

An antibody-based analytical method for the detection of a chemical flame retardant using antibody fragments isolated from an alpaca has been developed. One specific chemical flame retardant congener, 2,2',4,4'-tetrabrominated diphenyl ether (BDE-47), is often the major poly-BDE (PBDE) congener present in human and environmental samples and that which is the most frequently detected. An alpaca ...

We report the development of a novel time-resolved fluorescence immunoassay utilizing two different assay strategies for the simultaneous measurement of estrone-3-glucuronide (EG) and pregnanediol-3alpha-glucuronide (PG) in samples of early morning urine (EMU). The method for the measurement of EG involves the use of a labeled anti-idiotype as a surrogate antigen, whereas the other method (for ...

August 18, 2017 Type Package Title Evaluation of Surrogate Endpoints in Clinical Trials Version 0.4 Date 2017-08-18 Author Wim Van der Elst, Paul Meyvisch, Ariel Alonso, Hannah M. Ensor, Christopher J. Weir & Geert Molenberghs Maintainer Wim Van der Elst Description In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness ...