Given a randomized treatment Z, a clinical outcome Y, and a biomarker S measured some fixed time after Z is administered, we may be interested in addressing the surrogate endpoint problem by evaluating whether S can be used to reliably predict the effect of Z on Y. Several recent proposals for the statistical evaluation of surrogate value have been based on the framework of principal stratifica...

Advances in optimization technology, a cornerstone in engineering modeling, simulation-based design and manufacturing, continue to push back the boundaries of feasibility. Multi-disciplinary optimization continues to show success. Notwithstanding advances in computing power and user-friendly management of multidisciplinary software, challenging problems will undoubtedly continue to plague the d...

This paper deals with the development of effective techniques to automatically obtain the optimum management of petroleum fields aiming to increase the oil production during a given concession period of exploration. The optimization formulations of such a problem turn out to be highly multimodal, and may involve constraints. In this paper, we develop a robust Particle Swarm algorithm coupled wi...

Currently in our clinic, a mega-voltage cone beam computed tomography (MVCBCT) scan is performed before each treatment for patient localization. For nonsmall cell lung cancer (NSCLC) patients, a strain gauge is used as an external surrogate to indicate tumor motion in both the planning stage and the treatment stage. However, it is likely that the amplitude of tumor motion varies between treatme...

In this paper, an energy-management strategy based on fuel economy is presented to achieve a further range increase for range-extended light commercial vehicles. Estimation of the was carried out using neural-network-based surrogate model vehicle. Surrogate-based optimization plays important role in problems, which are complex structures with uncertainties data sets due various conditions. Neur...

  One of an important factor in the success of organizations is the efficiency of knowledge flow. The knowledge flow is a comprehensive concept and in recent studies of organizational analysis broadly considered in the areas of strategic management, organizational analysis and economics. In this paper, we consider knowledge flows from an Information Technology (IT) viewpoint. We usually have tw...