Class switch DNA recombination (CSR) crucially diversifies Ab biologic effector functions. 14-3-3γ specifically binds to the 5'-AGCT-3' repeats in the IgH locus switch (S) regions. By interacting directly with the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3γ targets this enzyme to S regions to mediate CSR. In this study, we showed that 14-3-3γ was expressed in germi...

Cell cycle progression is a tightly controlled process. To initiate cell division, mitogens trigger a number of early signals that promote the G(0)-G(1) transition by inducing cell growth and the activation of G(1) cyclins. Activation of cyclin E/cdk2 (cyclin-dependent kinase 2) at the end of G(1) is then required to trigger DNA synthesis (S phase entry). Among the early signals induced by mito...

Malaria is a vector-borne infectious disease caused by unicellular, obligate intracellular parasites of the genus Plasmodium. During host switch the malaria parasite employs specialized latent stages that colonize the new host environment. Previous work has established that gametocytes, sexually differentiated stages that are taken up by the mosquito vector, control expression of genes required...

The present study intended to compare the complaint responses used by President Rouhani and President Obama in the Iranian and US news interview contexts. For this purpose, Boxer’s (1993) six types of indirect complaint responses were adopted: ‘ignorance’, ‘questions’, ‘topic switch’, ‘contradiction’, ‘joke/teasing’, ‘advice/lecture’ and ‘agreement/commiseration’. The transcripts of the live ne...

In this paper an efficient high step-up converter with a coupled- inductor with soft- switching operation is presented. The proposed topology includes a coupled-inductor boost converter for raising the voltage gain. Moreover, a simple auxiliary resonant circuit composed of an auxiliary switch, a clamping diode and a resonant tank (inductor, capacitor), is adopted in this paper. The coupled-indu...

In this paper, a new structure of step-up dc-dc converter by using coupled inductor and active-clamped circuit is proposed. The proposed converter generates high voltage gain in comparison with the conventional dc-dc converters. Duo to using active-clamped circuit in the proposed topology the voltage stress on main switch is reduced. In addition the zero voltage switching (ZVS) in ON-state of m...

The accumulation of storage compounds in the starchy endosperm of developing cereal seeds is highly regulated at the transcriptional level. These compounds, mainly starch and proteins, are hydrolyzed upon germination to allow seedling growth. The transcription factor HvGAMYB is a master activator both in the maturation phase of seed development and upon germination, acting in combination with o...

OBJECTIVE Hydrostatic devices have considerable advantages compared to "conventional" differential-pressure-valves concerning overdrainage, but are thought to imply a tendency to underdrain or to clog. The aim of this study was to evaluate the ability of the hydrostatic gravitational Dual-Switch-Valve (DSV) to minimize overdrainage-related complications without increasing the danger of underdra...

BACKGROUND Medical choices often evoke great value uncertainty, as patients face difficult, unfamiliar tradeoffs. Those seeking to aid such choices must be able to assess patients' ability to reduce that uncertainty, to reach stable, informed choices. OBJECTIVE The authors demonstrate a new method for evaluating how well people have articulated their preferences for difficult health decisions...

Ethyl pyruvate (EP), a stable lipophilic pyruvate derivative, has been shown to exert anti-inflammatory activities through inhibiting the expression of various pro-inflammatory mediators as well as circulating levels of high mobility group box protein 1 (HMGB1) in a variety of in vitro and in vivo model systems. Necrotic cell death triggers an inflammatory response through release of HMGB1 in t...