Forkhead box P3 (FOXP3)(+)CD4(+)CD25(+) inducible regulatory T (iT reg) cells play an important role in immune tolerance and homeostasis. In this study, we show that the transforming growth factor-beta (TGF-beta) induces the expression of the Runt-related transcription factors RUNX1 and RUNX3 in CD4(+) T cells. This induction seems to be a prerequisite for the binding of RUNX1 and RUNX3 to thre...

A link is a finite family of disjoint, smooth, oriented or unoriented, closed curves in R or equivalently S. A knot is a link with one component. The Jones polynomial VL(t) is a Laurent polynomial in the variable √ t which is defined for every oriented link L but depends on that link only up to orientation preserving diffeomorphism, or equivalently isotopy, of R. Links can be represented by dia...

A link stream is a collection of triplets (t,u,v) indicating that an interaction occurred between u and v at time t. Link streams model many realworld situations like email exchanges between individuals, connections between devices, and others. Much work is currently devoted to the generalization of classical graph and network concepts to link streams. In this paper, we generalize the existing ...

Superconductors are excellent thermal insulators at low temperatures owing to the presence of an energy gap in their density states1. Through so-called proximity effect2, superconductors can influence states nearby metallic or superconducting wires. In this way, local a wire be tuned by controlling phase bias (φ) imposed across it3. Here we demonstrate quantum interference transistor (T-SQUIPT)...

Stromal interaction molecule 1 (STIM1) deficiency is a rare genetic disorder of store-operated calcium entry, associated with a complex syndrome including immunodeficiency and immune dysregulation. The link from the molecular defect to these clinical manifestations is incompletely understood. We report two patients with a homozygous R429C point mutation in STIM1 completely abolishing store-oper...

Immune responses are highly energy-dependent processes. Activated T cells increase glucose uptake and aerobic glycolysis to survive and function. Malnutrition and starvation limit nutrients and are associated with immune deficiency and increased susceptibility to infection. Although it is clear that immunity is suppressed in times of nutrient stress, mechanisms that link systemic nutrition to T...