Metastasis is the spread of disease from one organ or part of it to another non-adjacent organ or part. When the cancer cells at the originating site become clinically detectable, it is called a primary tumour. Metastasis of systemic primary tumours to oral cavity is uncommon. Such metastatic carcinomas involve the jaw bones and the oral soft tissues. Metastatic carcinomas in oral region can be...

A 7 cm diameter presacral tumour, not related to the intrapelvic organs, was found in a 51 year old woman. The needle biopsy showed a poorly differentiated large cell carcinoma. The patient died of urosepsis after chemotherapy. Postmortem examination revealed no other primary or metastatic tumour. Histological examination of the presacral tumour showed a large cell carcinoma with a trabecular p...

This article considers a mathematical model for tumour growth based on an acid-mediated hypothesis, i.e. the assumption that tumour progression is facilitated by acidification of the region around the tumour-host interface. The resulting destruction of the normal tissue environment promotes tumour growth. We will derive and analyse a reaction-diffusion model for tumour progression that includes...

Chordoid glioma is a rare benign neoplasm of uncertain histogenesis occurring in the third ventricle/ /suprasellar region. Recently, data have emerged suggesting that chordoid glioma is a variant of ependymoma related to a specialised ependyma of the subcommisural organ or the lamina terminalis area. In this study, we report clinicopathological and ultrastructural findings in two chordoid gliom...

Abstract Background Thymic epithelial tumours (TET) are rare thoracic cancers with reported annual incidence of 1.3–3.2 per million. TETs histologically classified as thymomas or thymic carcinomas. Thymomas slow-growing that comprise the majority lesions found in anterior mediastinum. They can be associated autoimmune disorders such Myasthenia Gravis. Contrast CT is standard for diagnosis. Surg...

CONTEXT AND OBJECTIVE Studies have shown that physiopathological changes to the respiratory system can occur following thoracic and abdominal surgery. Laminectomy is considered to be a peripheral surgical procedure, but it is possible that thoracic spinal surgery exerts a greater influence on lung function. The aim of this study was to evaluate the pulmonary volumes and maximum respiratory pres...

OBJECTIVES The surgical outcome of neurogenic tumours arising at the thoracic apex remains largely undefined. In this retrospective study, we compared the efficacy and safety of thoracoscopic surgery and thoracotomy for neurogenic tumours at the thoracic apex in 63 patients who received surgical treatment between 1992 and 2012 at our medical centre. METHODS Forty-four (69.8%) patients receive...

In 1970 a 20 year old woman presented with a pituitary chromophobe adenoma for which she underwent transfrontal pituitary surgery. In 1978 she had to be reoperated on because of local tumour recurrence, resulting in hypopituitarism. Bromocriptine (5 mg/day) was given for 15 years, but the plasma prolactin levels remained elevated. In 2000 the patient presented with signs and symptoms suggestive...

BACKGROUND Lymph node metastasis is commonly found in carcinoma of the thoracic oesophagus, even when the tumour invades only the submucosa. Although lymph node status greatly influences the outcome, the pattern of early lymphatic spread has not been investigated, and the role of lymph node dissection is still a matter of controversy. METHODS A series of 110 patients with superficial carcinom...