Urticarial vasculitis (UV) is a protean disorder that can be triggered by myriad of causes although it often idiopathic. Treatment successful with corticosteroids and/or immunosuppressive drugs. However, when cause found, specific treatment the underlying problem or removal an offending agent will resolve symptoms. This report describes patient UV thyroid replacement, necessitated Hashimoto's t...

Pendred syndrome is an autosomal recessive disorder characterized by congenital deafness and thyroid goiter. The thyroid disease typically develops around puberty and is associated with a mild organification defect, characterized by an inappropriate discharge of iodide upon perchlorate stimulation (a positive perchlorate discharge test). The gene (PDS) mutated in Pendred syndrome is expressed i...

CONTEXT There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders...

Mendelian genetics forms the basis for gene-informed risk assessment and management for the patient and family, and should be at the very foundation of 21st century personalization of healthcare. Yet this is an underutilized commodity. Identification and characterization of germline mutations in the RET proto-oncogene, encoding a receptor tyrosine kinase, as causing >90% of multiple endocrine n...

The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an inc...

Thyroid associated ophthalmopathy is an autoimmune disorder affecting the orbital and periorbital tissues. Hyperthyroidism is commonly associated with thyroid associated ophthalmopathy, however in 5% to 10% of cases it is euthyroid. Genetic, environmental and endogenous factors play a role in the initiation of the thyroid ophthalmopathy. Smoking has been identified as the strongest risk factor ...

Subclinical thyroid dysfunction (STD) represents a condition of slight thyroid hormone excess or deficiency, which may be associated with important adverse effects. This review will focus on the natural history, diagnosis and management of subclinical thyroid dysfunction. Since STD is only detected as a thyroid stimulating hormone (TSH) abnormality, it is essential to exclude transient causes o...

The present study included 340 inpatients of SMI Hospital admitted during the period January 2014 to December 2014 to study thyroid hormone profile in critically ill patients. The patients with history of thyroid disorders or any family history of thyroid disorders were excluded from the study. Serum free triiodothyronine (fT3), free tetraiodothyronine (fT4) and TSH (Thyroid Stimulating Hormone...

Background: Thyroid disease (TD) is the most common endocrine disorder associated with HCV infection, especially in conjunction with interferon-α (IFN-α)-based therapy. The aim of the work was to evaluate the role of thyroid dysfunction in HCV treated patients with combination therapy of interferon and ribavirin and correlate it with fibrosis stage. Materials and Methods: A retrospective study ...