ethosomes are a novel and alternative drug delivery systems and currently the focus of many research activities. ethosomes are soft, flexible vesicles that are composed mainly of phospholipids, ethanol and water. ethosomes can provide better skin permeation than liposomes and deliver enhanced amounts of both small and large therapeutic agents through skin and targeting to deeper skin layers for...

Transdermal drug delivery system has been accepted as potential noninvasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal antiinflammatory drugs (NSAIDs) represents the most commonly used medications for the treatment of pain and inflamma...

• 2 6 7 H O S P I TA L P H A R M AC I S T Pluronic lecithin organogel (PLO), a base in which drugs can be incorporated, is currently generating great interest in the US as a topical and transdermal drug delivery vehicle. Compounding pharmacists are advertising the vehicle, as well as their compounding services, and a large number of drugs have already been incorporated within PLO for human and ...

A matrix-type transdermal therapeutic system was developed for treating diseases of the eye where it is difficult for drug molecules to reach with conventional topical instillation. Prednisolone was employed as a model drug. An in vivo study using rats showed that the daily application of the patch maintained a constant plasma concentration of the drug, which was equivalent the therapeutic plas...

Chest wall tuberculosis (TB) is an endemic disease with a large number of variants. The condition affects numerous parts of the body and can penetrate the skin to form chronic open ulcers. Current treatment methods include oral anti-TB drugs and surgery. However, conventional drug treatments are not effective due to the difficulty in achieving an effective local concentration, and certain patie...

Infectious disease is a global problem and it effects almost all sections of peoples. A number of microorganisms are available to cause a variety of diseases. The infectious disease has tremendous impact on human health which has made the life miserable. The basic treatment for the infectious disese is the use of antimicrobials and the use of vaccination. Both of the above methods have the side...

The aim of this study was to compare the efficacy and safety of transdermal and oral routes of diclofenac for postoperative pain management in patients undergoing dental implant placement. Twenty systemically healthy, partially edentulous patients who required dental implants bilaterally in the mandibular first molar region were included. While the patient was under local anesthesia, an implant...

The present work showed that the iontophoretic approach was feasible to enhance transdermal drug delivery of drug. In vitro horizontal cell has been developed to co-relate with in vivo iontophoretic drug delivery more closely. Two electrodes were positioned on the either side of the epithelial. Iontophoretic delivery of Diltiazem HCl across porcine ear skin increased proportional to (a) Increas...

Aim: The objective of the present research work was to formulate and compare two different kinds of penetration enhancer in transdermal patch with placebo patch using a drug (Salbutamol sulphate) and compare for in vitro drug release. Study Design: The transdermal patches of Salbutamol sulphate were prepared by solvent evaporation technique using different ratios of Hydroxy propyl methylcellulo...