BACKGROUND Data from RNA-seq experiments provide a wealth of information about the transcriptome of an organism. However, the analysis of such data is very demanding. In this study, we aimed to establish robust analysis procedures that can be used in clinical practice. METHODS We studied RNA-seq data from triple-negative breast cancer patients. Specifically, we investigated the subsampling of...

It was built upon the overwhelming success of seven previous symposia hosted by JSU. The program of the Ninth International Symposium on Recent Advances in Environmental Health Research provided a strong forum to discover the latest scientific advances in the areas of environmental science and public health. The Symposium's program had continued to have a special appeal to scientists and engine...

It has been 9 years since Mr. Jesse Gelsinger died from complications of vector administration in a liver gene therapy trial of research subjects with a deficiency of ornithine transcarbamylase (OTCD). This study was performed at the Institute for Human Gene Therapy of the University of Pennsylvania (Penn) which I directed. His tragic death provoked a series of events that had implications beyo...

What an exciting year in stem cell science and translational medicine! STEM CELLS Translational Medicine (SCTM) and its sister journal, STEM CELLS (www.Stemcells.Com, @StemCellsJournal), with its focus on a better understanding of stem cell function, continued to publish remarkable, groundbreaking findings that are moving the field forward. And, in the regulatory arena, the U.S. Food and Drug A...

Although translational medicine has become a priority for medical science, advances in neuroscience have failed to be translated for the benefit of patients. In populations at high risk of psychosis, neuroimaging could stratify those mostly likely to develop psychosis. This is an example of potentially translatable psychiatry.

The field of tissue engineering has expanded at a staggering rate. In terms of bone tissue engineering research alone this has been represented by a dozen or so manuscripts being published in 1990, increasing to almost 18,000 at the time of writing. This is compounded by the fact that the tissue engineering market is estimated to be approximately 90 billion USD by 2016 [1]. Even so, the leap fr...

OBJECTIVES To summarize current excellent research in the field of health and clinical management. METHOD Synopsis of the articles selected for the IMIA Yearbook 2007. RESULTS Five articles from international peer reviewed journals were selected for the section on health and clinical management of the IMIA Yearbook 2007. They represent outstanding research on computerized provider order ent...

A39 Long-term depression-like effect of a single immune challenge in neuropeptide Y Y2 and Y4 receptor knockout mice Evelin Painsipp, Herbert Herzog, Günther Sperk and Peter Holzer Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria Neurobiology Research Program, Garvan Institute of Medical Res...