Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...

Thioridazine (TZ) is used mainly in the treatment of schizophrenia. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. In this context, we examined the cytotoxic mechanisms of TZ on freshly isolated rat hepatocytes to better understanding of the pathogenesis of TZ-induced hepatotoxicity. Hepatocytes were prepared by the method of collagenase enzyme...

Objectives To explore patients' preferences and experiences regarding intercultural communication which could influence the development of intercultural patient-centred communication training. Methods This qualitative study is based on interviews with non-native patients. Thirty non-native patients were interviewed between September and December 2015 about their preferences and experiences re...

In this report, experimental investigation of waste water treatment by reverse osmosis to enable its reuse in cooling tower is presented. A polyamide spiral wound RO membrane followed by three filters as RO pretreatment (two activated carbon and one cartridge filter) and samples of Tehran refinery treated waste water have been used. The effect of operating conditions such as pressure difference...

abstract mercury compounds are widely used in several industries. such compounds can find their way to the environment causing its pollution. mercury is considered as a powerful carcinogenic agent. on the other side, the garlic extract is characterized by having compounds of specific anticarcinogenic action. therefore, the present study was conducted to investigate both the genotoxicity and cyt...

Tumours of the head and neck have been treated by a cytotoxic drug given via the arterial supply. A simple anaesthetic technique is described. Related problems are considered, such as difficulty in intubation, difficulty in assessing skin colour following the injection of dye, and acute respiratory obstruction after operation from reactionary oedema in the tumour. Indications for tracheostomy a...

The antigenicity of promastigotes of Leishmania braziliensis braziliensis (L. b. braziliensis) treated with 1% sodium desoxycholate in 10 mM Tris-Hcl pH 8.2 was analysed by immunoblot using as probes sera from American cutaneous leishmaniasis (ACL), American visceral leishmaniasis (AVL), schistosomiasis, malaria and Chagas' disease. The ACL sera reacted constantly with a 60 kD band. No reactivi...