Diacylglycerol acyltransferases (DGATs) catalyze the final and only committed step of triacylglycerol synthesis. DGAT activity is rate limiting for triacylglycerol accumulation in mammals, plants and microbes. DGATs belong to three different evolutionary classes. In Arabidopsis thaliana, DGAT1, encoded by At2g19450, is the major DGAT enzyme involved in triacylglycerol accumulation in seeds. Unt...

Due to the rising depletion of fossil fuels and increased energy demands, human society is looking for clean sustainable energy. Commercially produced algal biodiesel limited by expense difficulty oil extraction subsequent conversion technologies. Microalgae with high content are only alternatives decreasing fuel supplies, but more work remains be done improve lipid microalgae strains. In this ...

The purpose of the present study was to investigate the context of lipid metabolism research in physical activity, lipolysis, lipolysis hormone regulation and the fate of lipolysis products in exercise, fatty acid transporters, some genes involved in lipid metabolism, effect of resistance activity on lipolysis, adaptations of adipose tissue due to physical activity, lipoproteins and apoproteins...

Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and FAs in most living organisms. Excessive accumulation of TGs, however, is associated with human diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and the only committed step in the biosynthesis of TGs is catalyzed by acylCoA:diacylglycerol acyltransferase (DGAT) enzymes. The ...

Avigan, J., Williams, C. D. & Blass, J. P. (1970) Biochim. Biophys. Acta 218,381-384 Betteridge, D. J., Higgins, M. J. P. & Galton, D. J. (1975) Br. Med. J . 4,5W502 Brown, M. S. & Goldstein, J. L. (1976) Science 191,150-154 Brown, M. S., Faust, J. R. & Goldstein (1975) J. Clin. Invest. 55, 783-793 Christophe, J. & Popjhk, G. (1961) J. Lipid Res. 2,244-257 Danielsson, H. (1972) Steroids 20,63-7...

To study potential effects of hepatic cholesterol concentration on secretion of very-low-density lipoprotein (VLDL) by the liver, male rats were fed on unsupplemented chow, chow with lovastatin (0.1%), or chow with lovastatin (0.1%) and cholesterol (0.1%) for 1 week. Livers were isolated from these animals and perfused in vitro, with a medium containing [2-14C]acetate, bovine serum albumin and ...

In Western countries, the transport of triacylglycerols by plasma triacylglycerol-rich lipoproteins (chylomicra and very-low-density lipoproteins (VLDL)) accounts for approximately 100 g lipids/d and represents a major pathway in the delivery of energy to tissues. Fat emulsions have been developed to resemble endogenous chylomicra (Wretlind, 1981). However, if the particle size of emulsion drop...