In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can relieve glaucomatous optic neuropathy. Increased intracranial pressure can also reduce optic nerve damage in glaucoma patients, and a safe, effective and noninvasive way to achieve this is by increasing the intra-abdominal pressure. The purpose of this study was ...

BACKGROUND Clinical trial registries can be used to monitor the production of trial evidence and signal when systematic reviews become out of date. However, this use has been limited to date due to the extensive manual review required to search for and screen relevant trial registrations. Our aim was to evaluate a new method that could partially automate the identification of trial registration...

the aim of this study was to assess the efficacy and tolerability of the aqueous extract of echium amoenum in combination with ssris in patients with general anxiety disorder (gad). the study was an 8-week double-blind randomized clinical trial. thirty-seven adult outpatients who met the dsm-iv-tr criteria for gad based on the structured clinical interview participated in the trial. in this stu...

topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. in this study, isotretinoin-loaded solid lipid nanoparticles(it-sln) were prepared to treat the mild to moderate acne. also using it-sln would minimize it adverse effects in comparison to commercial product, isotrex®. this study was conducted to prepar...

aim and background: patients with ischemic heart disease in acute stage experienced great anxiety and in compared with patients had less anxiety were affected 5 times more to ischemia, re-infarction, tachycardia, arrhythmias and ventricular fibrillation.  excessive anxiety delays recovery and increases the probability of their death in the first month. numerous studies have shown that heart dis...

background: tocotrienols have been shown to improve glycemic control and redox balance in an animal study, but their effects on patients with diabetes are unknown. the study aimed to investigate whether tocotrienols improves glycemic control, insulin sensitivity,and oxidative stress in individuals with type 2 diabetes mellitus (t2dm). materials and methods: this study was a double-blinded,place...

normal 0 false false false en-us x-none ar-sa background: high prevalence of obesity and the importance of this issue as a risk factor for chronic diseases such as severe cardiovascular diseases, diabetes, and cancer necessitate the need for treatment. the aim of this study was the evaluation of acarbose effect on the weight loss in non-diabetic overweight or obese patients in kerman. materials...

primary dysmenorrhea refers to painful cramps during menstruation with no organic reason. with respect to its high incidence and adverse outcomes in quality of life and some evidences regarding the sedative and antispasmodic effects of melissa officinails on smooth muscles as an herb, this double-blind clinical trial was conducted to determine the effects of its capsules on severity of dysmenor...

background: designing the effective and early interventions can prevent progression of prediabetes to diabetes. few studies have shown the effect of flaxseed on glycemic control. this study aimed to assess the effect of flaxseed powder on insulin resistance (ir) indices and blood pressure in prediabetic individuals. materials and methods: in a randomized clinical trial, 99 prediabetic individua...