Isoimmunity to a methylcholanthrene-indueed fibrosarcoma and to a spontaneous breast adenocarcinoma was induced in female O3H/HeX mice. Circulating antitumor antibodies spé cifie for the particular immunizing tumor were detected in the immune mice. These antibodies did not appear until the primary tumors were surgically removed. Measurable amounts of anti body could be detected as long as 3.5 ...

Anti-idiotypic antibodies are regulatory antibodies responsible for the shutdown of active immune responses against growing tumor cells. In an attempt to study these antibodies, a technique for isolating specific anti-idiotypic antibodies by immunoaffinity chromatography was devised. Human anti-tumor antibodies were isolated by affinity absorption to fixed autologous tumor cells. These antibodi...

OBJECTIVES To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. METHODS AND RESULTS The expression of tenascin (TN) and fibronecti...

PURPOSE Previously, we have shown that the attachment of interleukin 2 (IL-2) to a tumor-targeting antibody can produce a 4-fold enhancement in the uptake of antibodies and drugs in tumors. More recently, we discovered that a 37-amino-acid linear sequence of IL-2 designated vasopermeability-enhancing peptide (PEP), contained the vasopermeability activity of IL-2, and could be used after linkage...

Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA is significantly elevated in most prostate tumors, as well as a significant fraction of ovarian and renal cell carcinomas and hepatomas. Although the overexpression of mRNA in these tumors has been extensively docum...

In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s,  Mahaley used monoclonal antibodies to treat central nervous system(CNS)  tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...

introduction:torch infections causing via toxoplasma gondii, other microorganisms (e.g., treponema pallidum), rubella virus, cytomegalovirus (cmv) and the herpes simplex virus (hsv) types 1 and 2 during the first trimester of pregnancy can lead to severe fetal anomalies or even fetal loss. the current study determined the serological data of torch infections in women who were in their first tri...

a survey was carried out in five provinces of iran (kerman, sistan and baluchestan, hormozgan, khorasan and yazd) for the presence of alfalfa mosaic virus (amv) sero-types in alfalfa during 2002 to 2003. the number of samples collected was 250, represent-ing the diversity and geographical distribution of amv in these areas. diagnosis was car-ried out using polyclonal (pabs) and monoclonal (mabs...

We used immunohistochemical procedures to study the cellular expression and distribution of cytokeratins (CKs) in rat 13762NF mammary adenocarcinoma cells growing at mammary fat pad sites and at spontaneous lymph node and lung sites. In order to establish CK distribution in normal rat mammary epithelia, immature, resting, and lactating rat mammary glands were probed with a panel of monospecific...

Hybridoma cultures secreting monoclonal antibodies were derived from fusions of parent myeloma P3-X63-Ag8 with spleen cells of F344 rats which had been immunized with the BALB/c alveolar lung carcinoma line 1. Screening of several thousand hybridoma cultures identified 55 cell lines making antibody that bound to the line 1 cell surface. Of 15 of these antibodies tested, seven could be identifie...