quantitative relationships between molecular structure of forty eight aldehyde compounds with their known cathepsin k inhibitory effects were discovered by partial least squares (pls) method. evaluation of a test set of 10 compounds with the developed pls model revealed that this model is reliable with a good predictability. since the qsar study was performed on the basis of theoretical descrip...

background: as a disease of motor nervous system (motor neuron  disease), amyotrophic  lateral  sclerosis (als)  has  a great  impact  on  several  aspects  of  quality  of  life (qol). generic questionnaires of qol do not address all the especial features  of als and  therefore  translation  and  validation of disease specific questionnaires such as amyotrophic lateral sclerosis assessment  qu...

in iran, most mountainous watersheds do not have enough hydrometery stations and defective stations have sparse data. because of limited availability of hydrologic data, watershed modeling plays a crucial role in development of local resources. in this study, swat was applied to simulate runoff in marun dam (idanak) watershed, a sub-basin of marun catchment. calibration and sensivity analyses w...

in this paper, the quantitative structure activity-relationship (qsar) of the ccr2b receptor inhibitors was scrutinized. firstly, the molecular descriptors were calculated using the dragon package. then, the stepwise multiple linear regressions (sw-mlr) and the genetic algorithm multiple linear regressions (ga-mlr) variable selection methods were subsequently employed to select and implement th...

in the present study, a model of a large lithium polymer (li-po) battery for use in the simulation of hybrid electric vehicles (hevs) is developed. to attain this goal, an equivalent circuit (ec) consisting of a series resistor and two rc parallel networks is considered. the accuracy and the response time of the model for use in an hev simulator are studied. the battery parameters identificatio...

a mathematical model was developed to predict the effects of wind speed, light, ph, temperature, dissolved carbon dioxide and chemical oxygen demand (cod) on dissolved oxygen (do) in fish ponds. the effects of organic feeds, aeration and fish activity were added to the model developed by kayombo et al. for waste stabilization ponds (ecological modeling 127(2000): 21-31) to reflect the situat...

mathematical models have the potential to provide a cost-effective, objective, and flexible approach to assessing management decisions, particularly when these decisions are strategic alternatives. in some instances, mathematical model is the only means available for evaluating and testing alternatives.  however, in order for this potential to be realized, models must be valid for the applicati...

conclusions we concluded that the fcchl scales are valid and reliable, and can be used to measure health literacy among iranian diabetic patients. however, further research is needed to establish stronger psychometric properties for the use of this questionnaire in iran. results exploratory factor analysis (efa) identified three main factors with 27.07%, 22.46%, and 16.23% of extracted variance...

objectives we aimed to translate the bapt into farsi, assess its content validity, and examine its reliability and validity to identify exclusive breastfeeding discontinuation in iran. materials and methods the bapt was translated into farsi and the content validity of the farsi version of the bapt was assessed. it was administered to 356 pregnant women in the third trimester of pregnancy, who ...