This study presents an in vitro experimental method to determine shear properties of the epidermis. Shear tests were performed with a parallel plate rheometer on samples of stratum corneum and the viable epidermis. The method was validated on very thin silicon sheets. Preliminary test were performed to determine the linear viscoelastic range, the effect of normal loading on the sample and the t...

A micromechanical modeling procedure is developed to predict the viscoelastic properties of a graphite nanoplatelet/epoxy composite as a function of volume fraction and nanoplatelet diameter. The predicted storage and loss moduli from the model are compared to measured values from the same material using Dynamical Mechanical Analysis, nanoindentation, and tensile tests. In most cases, the model...

The viscoelastic and dynamic nonlinear properties of guinea pig tracheal smooth muscle tissues were investigated by measuring the storage (G') and loss (G") moduli using pseudorandom small-amplitude length oscillations between 0.12 and 3.5 Hz superimposed on static strains of either 10 or 20% of initial length. The G" and G' spectra were interpreted using a linear viscoelastic model incorporati...

Poly(vinyl alcohol) (PVA) cryogel is a biocompatible, synthetic hydrogel, compatible with magnetic resonance (MR) imaging. It widely used as biomaterial in tissue scaffolds and mimics to test various diagnostic techniques. The aim of this study characterise the effect varying PVA concentration, molecular weight (MW) manufacturing protocol on viscoelastic mechanical properties MR T2 relaxation t...

In recent work it was clarified that amorphous solids under strain control do not possess nonlinear elastic theory in the sense that the shear modulus exists but nonlinear moduli exhibit sample-to-sample fluctuations that grow without bound with the system size. More relevant, however, for experiments are the conditions of stress control. In the present Rapid Communication we show that also und...

Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells. Here, we systematically evaluated the effect of age and cytoskeletal disruptors on the mechanical properties of chondrocytes as a function of deformation. We quantified the indentation-dependen...

Cherkaev-Gibiansky and Hashin-Shtrikman variational principles are utilized in order to obtain rigorous bounds on the shear modulus of two-phase viscoelastic composites in three dimensions. The simplest class of bounding regions is composed of circles in the complex plane containing four points related to the viscoelastic moduli of the constituents. By taking the intersection of all such circle...

Biological tissues are viscoelastic, demonstrating a mixture of fluid and solid responses to mechanical strain. Whilst viscoelasticity is critical for native tissue function, it is rarely used as a design criterion in biomaterials science or tissue engineering. We propose that viscoelasticity may be tailored to specific levels through manipulation of the hydrogel type, or more specifically the ...