نتایج جستجو برای: vntr genotyping
تعداد نتایج: 25021 فیلتر نتایج به سال:
A multiplex PCR method incorporating primers flanking three variable-number tandem repeat (VNTR) loci (arbitrarily labeled TR1, TR2, and TR3) in the CT18 strain of Salmonella enterica serovar Typhi has been developed for molecular typing of S. enterica serovar Typhi clinical isolates from several Asian countries, including Singapore, Indonesia, India, Bangladesh, Malaysia, and Nepal. We have de...
BACKGROUND Leptospirosis is a worldwide zoonosis that is endemic in tropical areas, such as Reunion Island. The species Leptospira interrogans is the primary agent in human infections, but other pathogenic species, such as L. kirschner and L. borgpetersenii, are also associated with human leptospirosis. METHODS AND FINDINGS In this study, a melting curve analysis of the products that were amp...
Various genetic markers such as IS-elements, DR-elements, variable number tandem repeats (VNTR), single nucleotide polymorphisms (SNPs) in housekeeping genes and other groups of genes are being used for genotyping. We propose a different approach. We suggest the type II toxin-antitoxin (TA) systems, which play a significant role in the formation of pathogenicity, tolerance and persistence pheno...
سابقه و هدف: تعدد جهش در ژن PAH (عامل PKU) باعث میشود که در بسیاری از موارد تشخیص جهش بیماریزا امکانپذیر نباشد. در این موارد برای شناسایی ناقلین از پلی مورفیسمهای درون و نزدیک ژن PAH استفاده میشود. VNTR (Variable Number of Tandem Repeat) یکی از مارکرهای چند آللی ژن PAH می باشد. در این مطالعه، فراوانی و توزیع آللهای VNTR ژن PAH در کلیه مبتلایان PKU شناخته شده استان یزد تا ابتدای سال 1387 ...
the miru-vntr polymorphism and katg463 mutation are used to genotype the mycobacterium tuberculosis, but the correlation between them and inh-resistance were unknown. this study was aimed to explore whether etre polymorphism and katg463 mutation could predict the inh-resistance, and the relationship between etre polymorphism and katg463 mutation.the etre, katg463 mutation and drug resistance in...
Background and Objective: Phenylketonuria (PKU) is a metabolic disorder that is caused by mutations in the phenylalanine hydroxylase (PAH) gene. The multiplicity of mutations in the PAH gene of PKU leads to the cases, in which the pathogenic mutation cannot be detected. In these cases, the variable number of tandem repeat (VNTR), which is the polymorphic marker associated with the PAH gene, is ...
BACKGROUND Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with an increased risk of type II diabetes mellitus. The results of previous research about the association of the VNTR polymorphism in 5-prime flanking region of the insulin (INS) gene with PCOS have been inconsistent. The present study was to investigate the association of the INS-VNTR polymorphism with PCOS...
The dopamine (DA) transporter DAT1 is a major target bound by cocaine in brain. We examined the influence of functional genetic variants in DAT1 on cocaine addiction. Repeat polymorphisms, including a 30-bp variable-number tandem repeat (VNTR) in intron 8 (Int8 VNTR) with two common alleles, were genotyped in cocaine-dependent abusers (n = 699) and in controls with no past history of drug abuse...
Variable-number tandem-repeat (VNTR) typing with a panel of 24 loci is the current gold standard in the molecular typing of Mycobacterium tuberculosis complex isolates. However, because of technical problems, a part of the loci often cannot be amplified by multiplex PCRs. Therefore, a considerable number of single-locus PCRs have to be performed for the loci with missing results, which impairs ...
•Detecting pathogenic variants in VNTRs is challenging due to poor read mappability•VNtyper detects VNTR the MUC1 gene using Kestrel algorithm•VNtyper improves ADTKD-MUC1 diagnosis by accurate genotyping of coding VNTR•Integration VNtyper with SRS panel testing identified new overlooked patients The human genome comprises approximately 3% tandem repeats variable length (VNTR), a few which have ...
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