Wnt signaling plays many important roles in animal development. This evolutionarily conserved signaling pathway is highly regulated at all levels. To identify regulators of the Wnt/Wingless (Wg) pathway, we performed a genetic screen in Drosophila. We identified the microRNA miR-8 as an inhibitor of Wg signaling. Expression of miR-8 potently antagonizes Wg signaling in vivo, in part by directly...

Background: Changes in temperature and precipitation pattern seriously affect the amount of river runoff coming into Dam Lake. These changes could influence the operating conditions of reservoir systems such as Jor hydropower reservoir system (Malaysia) with the total capacity of 150 MW. So, it is necessary to analyze the effect of changes in weather parameters on the river runoff and consequen...

The basins of the Júcar and Segura rivers, on Mediterranean coast Iberian Peninsula, present a special water problem are particular interest regarding climate change. These very vulnerable to possible scenario decreasing resources. Recent studies historic rainfall since 1955 have indicated an ongoing loss precipitation in their headwaters, especially case river. aim study is perform projections...

The purpose of model selection algorithms such as All Subsets, Forward Selection, and Backward Elimination is to choose a linear model on the basis of the same set of data to which the model will be applied. Typically we have available a large collection of possible covariates from which we hope to select a parsimonious set for the efficient prediction of a response variable. Least Angle Regres...

In order to correct the error that Efron et al pointed out modified Lars is a fast algorithm for lasso problem, computer simulation carried with data. The results show when variable removed first and then entered in variables selected by cannot be same. At this time, no matter how modify size of Lars, problem solved. method used errors paper, contribute development world data computing.