The building block hypothesis implies that genetic algorithm (GA) effectiveness is influenced by the relative location of epistatic genes on the chromosome. We demonstrate this effect in four experiments, where chromosomes with adjacent epistatic genes provide improved results over chromosomes with separated epistatic genes. We also show that information-theoretic reconstructability analysis ca...

In [HK14] an unlinkable version of the U-Prove attribute-based credential scheme is proposed. Unfortunately, the new scheme is forgeable: if sufficiently many users work together then they can construct new credentials, containing any set of attributes of their choice, without any involvement of the issuer. In this note we show how they can achieve this and we point out the error in the unforge...

Genome-wide association studies (GWAS) have become a standard method for finding genetic variations that contribute to common, complex diseases. Recently, it is suggested that these diseases may be caused by epistatic interactions of multiple genetic variations. Although tens of software tools have been developed for epistasis detection, few are able to infer pathway importance from the identif...

Study reveals that Tubby family proteins help deliver GPCRs and other integral membrane proteins into cilia.

Standard analysis methods for genome wide association studies (GWAS) are not robust to complex disease models, such as interactions between variables with small main effects. These types of effects likely contribute to the heritability of complex human traits. Machine learning methods that are capable of identifying interactions, such as Random Forests (RF), are an alternative analysis approach...

Efforts to identify loci underlying complex traits generally assume that most genetic variance is additive. Here, we examined the genetics of Arabidopsis thaliana root length and found that the genomic narrow-sense heritability for this trait in the examined population was statistically zero. The low amount of additive genetic variance that could be captured by the genome-wide genotypes likely ...