Researchers studying Y chromosome evolution have drawn attention to neo-Y chromosomes in Drosophila species due to their resembling the initial stage of Y chromosome evolution. In the studies of neo-Y chromosome of Drosophila miranda, the extremely low genetic diversity observed suggested various modes of natural selection acting on the nonrecombining genome. However, alternative possibility ma...

2-Deoxystreptamine (2-DOS) aminoglycosides exert their antibiotic actions by binding to the A site of the 16S rRNA and interfering with bacterial protein synthesis. However, the molecular forces that govern the antitranslational activities of aminoglycosides are poorly understood. Here, we describe studies aimed at elucidating these molecular forces. In this connection, we compare the bacterici...

Background: Patients with Trichotillomania (TC) have an irreversible urge to pull their hair.  This self-mutilation behavior is associated with high level of tension before and a sense of gratification and relief after TC. Objective: To investigate the personality characteristics of patients suffering from TC. Method: The study was performed on 43 TC patients and 43 gender and age-matched non-p...

PURPOSE Electrorotation (ROT) is a technique that allows for determination of the dielectric properties of living cells when exposed to a rotating electric field. We evaluated the ROT behavior of MCF/neo and p185(neu) transfectancts MCF/HER2-11 and MCF/HER2-18 to investigate whether differences in HER-2/neu expression were associated with differences in dielectric properties in these cells. E...

Background and Aim: It is necessary to consider the personality traits of patients to predict their behavior in dental office. This study was performed to determine the ef-fect of patients’ personality traits on their degree of satisfaction with prosthetic-implant therapy. Materials and Methods: In this study, 51 partially edentulous patients who had lost 1 to 4 maxillary premolars and 2 month...

IFN-alpha gene therapy has been successfully applied in several tumor models. Our studies involving the murine colorectal adenocarcinoma cell line MC38 confirm that IFN-alpha transduction of a poorly immunogenic tumor cell reduces tumorigenicity and leads to long-lasting tumor immunity. To investigate the effect of IFN-alpha transduction on the development of antitumor immune responses, we rest...

Neo-shamanism is a largely unexplored spiritual practice among Western peoples that, by virtue of its queerness, has pressing implications for archaeologists. In their practices, Druidic neo-shamans increasingly make pilgrimages to ancient sites and express strong views on the socio-politics of their presentation and management. Rather than avoid the ‘fringe’ and dismiss these engagements with ...

The aim of this study was to investigate the behavior of the protonated paralytic shellfish poisons saxitoxin (STX) and neosaxitoxin (NEO) in the gas-phase after ion activation using different tandem mass spectrometry techniques. STX and NEO belong to a group of neurotoxins produced by several strains of marine dinoflagellates. Their chemical structures are based on a tetrahydropurine skeleton ...