Oligomers that contain both α- and β-amino acid residues, or "α/β-peptides", have emerged as promising mimics of signal-bearing polypeptides that can inhibit or augment natural protein-protein interactions. α/β-Peptides that contain a sufficient proportion of β residues evenly distributed along the sequence can be highly resistant to enzymatic degradation, which is favorable with regard to in v...

insulin dependent diabetes mellitus (iddm) results from irreversible loss of beta cells (β-cells) of the pancreas. a streptozotocin (stz)-induced diabetes in animal model mimics, in some aspects, recent onset iddm. this study was conducted to investigate the effect of nicotinamide on experimentally-induced iddm. thirty spraque dawley rats were divided into 3 groups; a control group, a diabetic ...

High-resolution structures of peptide supramolecular assemblies are key to understanding amyloid diseases and designing peptide-based materials. This paper explores the supramolecular assembly of a macrocyclic β-sheet peptide derived from transthyretin (TTR). The peptide mimics the β-hairpin formed by the β-strands G and H of TTR, which form the interface of the TTR tetramer. X-ray crystallogra...

The inverse sequences of naturally occurring proteins display different folding and structural properties fail to retain the functions native despite identical fundamental features, such as amino acid composition, hydrophobicity, etc. To gain insight into physical mechanisms underlying secondary structure formation aggregation direct retro amyloidogenic peptides, we probed fibrillogenesis accom...

Carbohydrate recognition is essential in cellular interactions and biological processes. It is characterized by structural diversity, multivalency and cooperative effects. To evaluate carbohydrate interaction and recognition, the structurally defined attachment of sugar units to a rigid template is highly desired. β-Peptide helices offer conformationally stable templates for the linear presenta...

Background Considering the increasing prevalence of type 1 diabetes mellitus (T1DM) as an autoimmune disease in recent years and the positive effects of vitamin D (VD) on this disease, especially the preventive effect of VD on progressive reduction of pancreatic β-cells, we aimed to investigate the effect of VD on pancreatic β-cell function in T1DM patients. Materials and Methods From Sep 2016 ...

OBJECTIVE To examine persistence of C-peptide production by ultrasensitive assay years after onset of type 1 diabetes and factors associated with preserving β-cell function. RESEARCH DESIGN AND METHODS Serum C-peptide levels, a marker of insulin production and surviving β-cells, were measured in human subjects (n = 182) by ultrasensitive assay, as was β-cell functioning. Twenty-two times more...

Peptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretwo major chemical techniques for peptidesproduction.In this research, the synthesis ofdipeptde(β-alanine-L-histidine)wasexamined...

A strategy was developed to extend the lifetime of an peptide-based substrate for Abl kinase in the cytosolic environment. Small β-turn structures were added to the peptide's N-terminus to block entry into peptidase catalytic sites. The influence of the size of the β-turn and two covalent cross-linking strategies on the rate of hydrolysis was assessed. The most peptidase-resistant substrate was...

The design of β-peptide foldamers targeting the transmembrane (TM) domains of complex natural membrane proteins has been a formidable challenge. A series of β-peptides was designed to stably insert in TM orientations in phospholipid bilayers. Their secondary structures and orientation in the phospholipid bilayer was characterized using biophysical methods. Computational methods were then devise...