Motivation: Many methods predict the physical interaction between two proteins (protein-protein interactions; PPIs) from sequence alone. Their performance drops substantially for proteins not used for training. Results: Here, we introduce a new approach to predict PPIs from sequence alone which is based on evolutionary profiles and profile-kernel support vector machines. It improved over the st...

یکی از جذاب ترین روش های ماشینکاری مدرن، تخلیه الکتریکی است که در اواخر دهه 1960 معرفی شد. با سیم کاربردهای مختلفی دارد، جمله دقت بالا تمام مواد رسانا مانند فلزات، آلیاژهای فلزی، گرافیت و سرامیک همچنین صنایع هوافضا، خودروسازی سایر صنایع. به منظور افزایش سرعت کاهش زبری سطح عرض شکاف، پارامترهای برش بهینه نقش مهمی انتخاب خروجی دارند. این مطالعه، ورودی (دبی، مدت پالس، فرکانس سیم، کشش جریان دی الکتر...

Jane Maienschein is the daughter of Joyce Kylander [5] and Fred Maienschein [6], and was born in Oak Ridge, Tennessee, on 23 September 1950. She attended MIT as a freshman and then transferred to Yale University [7] in 1969 when Yale decided to admit women undergraduates. In 1972 she graduated with an honors degree in History, the Arts, and Letters having written a thesis on the history of scie...

ONE of the duties incumbent upon an international scientific organization is the establishment of a system of standard measures and methods for general use within its particular science. In ophthalmology, this need was beginning to be felt at the end of the 19th century, and at the X Ophthalmological Congress which was held at Lucerne in 1904 the Societe franQaise d'Ophtalmologie made certain p...

Apical and basolateral determinants specify and maintain membrane domains in epithelia. Here, we identify new roles for two apical surface proteins – Cadherin 99C (Cad99C) and Stranded at Second (SAS) – in conferring apical character in Drosophila tubular epithelia. Cad99C, the Drosophila ortholog of human Usher protocadherin PCDH15, is expressed in several embryonic tubular epithelial structur...