OBJECTIVE We previously demonstrated that a reduced number of CD(4+)CD(25+)-regulatory T cells (Tregs) was associated with microvascular dysfunction in hypertension. However, the underlying mechanism by which Tregs regulate vascular endothelial function remains unknown. METHODS AND RESULTS Control and interleukin (IL)-10(-/-) knockout mice were infused with angiotensin II (400 ng/kg/min) for ...

Dioscoreae Rhizome (DR) has been used in traditional medicine to treat numerous diseases and is reported to have anti-diabetes and anti-tumor activities. To identify a bioactive traditional medicine with anti-inflammatory activity of a water extract of DR (EDR), we determined the mRNA and protein levels of proinflammatory cytokines in macrophages through RT-PCR and western blot analysis and per...

Rationale: Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear. Objective: UCP2 protects against endothelial dysfunction induced by high-fat diet through inhibition of r...

Deriving respiratory signal from a surface electrocardiogram (ECG) measurement has advantage of simultaneously monitoring of cardiac and respiratory activities. ECG-based cardiopulmonary coupling (CPC) analysis estimated by heart period variability and ECG-derived respiration (EDR) shows promising applications in medical field. The aim of this paper is to provide a quantitative analysis of the ...

Electrodermal activity (EDA) refers to the electrical activity measured on and under the surface of the skin and has been used to study sleep, stress, and mood. While gathering this signal was once confined to the laboratory, it can now be acquired in ambulatory studies through commercially available wearable sensors. In this thesis, we model and analyze electrodermal response (EDR) events (1-5...

This note investigates the dose response of layered HS Gafchromic film compared to Kodak EDR-2 radiographic film. Using five layers of HS type Gafchromic film a dose response greater than EDR-2 film is achieved at the peak wavelength (0.55 OD/Gy versus 0.3 OD/Gy for EDR-2 film). Even over a broader waveband of 30 nm, which is similar to that found in ultra bright LED scanners, the response was ...

A commercial aircraft, departing from Seoul to Jeju Island in South Korea, encountered a convectively induced turbulence (CIT) at about z = 2.2 km near on 28 October 2018. At this time, the observed radar reflectivity showed that convective band with cloud tops of 6–7 passed CIT region high values spectral width (SW; larger than 4 m s–1). Using 1 Hz wind data recorded by we estimated an objecti...

Nuclear genome duplication is normally restricted to once per cell division, but aberrant events that allow excess DNA replication (EDR) promote genomic instability and aneuploidy, both of which are characteristics of cancer development. Here we provide the first comprehensive identification of genes that are essential to restrict genome duplication to once per cell division. An siRNA library o...

RATIONALE Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear. OBJECTIVE UCP2 protects against endothelial dysfunction induced by high-fat diet through inhibition of r...