Background and purpose: Harmane, norharmane and harmine are -carboline members of the family of Harmalas alkaloids (Peganum harmala, Zygophillaceae). The -carboline alkaloids bind to benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptors as inverse agonists. This finding suggests that the harmane, norharmane and harmine might attenuate the hot-plate and formalin-induced noci...

Background and purpose: b-carboline alkaloids, also known as harmala's alkaloids have a wide spectrum of pharmacological actions including a stimulatory action on release of dopamine and other catecholamines in several brain regions and an inhibitory action on monoamine oxidase (MAO). These findings suggest that b-carbolines should alleviate at least some of the dopaminergic stereotyped behav...

In acute leukaemia, the maturation of the malignant cells is arrested and the cells merely proliferate. In the recent years, beside chemotherapy combination of differential factors cytokins and cytotoxic agents have been used in treatment of acute leukaemia particularly acute promyelocytic leukaemia. The present study was an evaluation of proliferation, cytotoxicity and differentiatio...

یک روش کروماتوگرافی لایه نازک که با پردازش عکس کوپل شده است جهت تجزیه کمی همزمانی بعضی از گونه های بی رنگ بتا کربولین (مانند هارمالین، هارمین و هارمالول) در دانه های اسفند بهبود پیدا کرد. همچنین نیفدپین و محصول تخریب نوری آن به طور همزمان در فراورده های دارویی توسط روش پیشنهاد شده تعیین مقدار شد. علاوه بر اینmia-tlc جهت تجزیه کیفی مانند طبقه بندی دانه های اسفند در مناطق مختلف ایران به کار بسته ...