The two known estrogen receptors, ER and ER , are hormone-inducible transcription factors that have distinct roles in regulating cell proliferation and differentiation. Previously, our laboratory demonstrated that ER exhibits stereoselective ligand binding and transactivation for several structural derivatives and metabolites of the synthetic estrogen diethylstilbestrol. We have previously desc...

Bennett, R. S., Spurgeon, D. W., DeTar, W. R., Gerik, J. S., Hutmacher, R. B., and Hanson, B. D. 2011. Efficacy of four soil treatments against Fusarium oxysporum f. sp. vasinfectum race 4 on cotton. Plant Dis. 95:967-976. Fusarium wilt, caused by race 4 of Fusarium oxysporum f. sp. vasinfectum, is a critically important disease problem in California cotton (Pima, Gossypium barbadense; Upland, ...

Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, but the phenotype becomes evident only after puberty. During childhood, and even during early puberty, pituitary-gonadal function in 47,XXY subjects is relatively normal, but from midpuberty onwards, FSH and LH levels increase to hypergonadotropic levels, inhibin B decreases to undetectable levels, and testosterone ...

We recently performed an updated network meta-analysis (NMA) to inform the British Association of Dermatologists guidelines for biologic therapy psoriasis (Smith et al., 2020Smith C.H. Yiu Z.Z. Bale T. Burden A.D. Coates L.C. Edwards W. al.British 2020 – a rapid update [e-pub ahead print].Br J Dermatol. 2020; 183: 628-637Crossref PubMed Scopus (39) Google Scholar). During this process, we ident...

With nature-based offsets emerging as a core strategy for meeting near-term climate targets, it is essential they deliver real and verifiable mitigation gains. However, the interventions that generate can have unintended effects cause carbon leakage ultimately reduce mitigation. Although "old news" various anti-leakage measures been considered, there little evidence current practices to address...

In recent years, many new concepts and technologies were introduced to improve the efficiency of ground vehicle propulsions. When these techniques were integrated together, they were usually designed individually and the integrated system may not work as efficiently as it potentially could be. A joint research between the University of Michigan and the General Motors Powertrain over the last th...