Rofecoxib was originally submitted as an NDA in November 1998 and approved by the Agency in May 1999 for the relief of sign and symptom of osteo-arthritis (OA) and for the management of acute pain and dysmenorrhea. The current approved maximum dose was 25 mg daily for OA and 50 mg daily for acute pain. The purpose of this supplemental NDA submission was to provide evidence for label revision to...

Offset pulse position modulation (OPPM) and Dicode (DiPPM) have been introduced as new attractive techniques, however, they are suffering from erasure, wrong slot, false alarm errors. in this paper, two types of error correction (EC) codes, Low-Density Parity Check (LDPC) code Reed Solomon (RS) code, where paired the OPPM DiPPM systems to reduce bugs, analyze best EC parameters, choose superlat...

In April 2001, three instrumented surface drifters were deployed in the Mississippi River plume near the mouth of Southwest Pass. The plume was characterized by strong surface gradients of salinity, temperature, and chromophoric dissolved organic matter fluorescence (FCDOM). The drifters initially headed west and attained peak speeds of 1 m s 1 within 5 h after release. Thereafter, velocity dec...

to evaluate the effect of supplemental vitamin c (vc) levels on performance and immune response of broiler chicks, 300 day-old ross male broiler chicks were allocated to a completly randomized design of 5 treatments(500 and 1000 ppm in diet, 500 and 1000 ppm in drinking water and control). immunity was assessed as antibody production against infectious bronchitis virus (ibv) and newcastle disea...