introduction: anxiety is among the most common and treatable mental disorders. adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. the elevated plus-maze (epm) has broadly been used to investigate anxiolytic and anxiogenic compounds. the present study investigated the effects of intraperitoneal (ip) injection of cannabinoid cb1 receptor antagonist (am251) i...

l-Glutamate (Glu) activates at least eight different G protein-coupled receptors known as metabotropic glutamate (mGlu) receptors, which mostly act regulators of synaptic transmission. These consist two domains: an extracellular domain in agonists bind and a transmembrane heptahelix region involved protein activation. Although new mGlu receptor antagonists have been described, few are selective...

In the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (WSS) on naloxone-induced jumping in morphine-dependent mice were examined. Mice were rendered dependent as described in the methods section. The opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). The first group exposed to WSS in the pr...

in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...

Background: Novel roles for the interaction of cardiotonic steroids to Na+/K+-ATPase have been established in recent years. The aim of the present study was to investigate the intracellular signaling events downstream the action of ouabain on Na+/K+-ATPase in Sertoli cell obtained from immature rats. Treatment of Sertoli cells with ouabain (1 μM) induced a rapid and transient increase in the ex...