Quantification methods employing stable isotope-labeled peptide standards and liquid chromatography–tandem mass spectrometry are increasingly being used to measure enzyme amounts in biologic samples. Isoform concentrations, combined with catalytic information, can be used in absorption, distribution, metabolism, and excretion studies to improve accuracy of in vitro/in vivo predictions. We quant...

Despite accruing evidence for relative preservation of episodic memory in the semantic variant of primary progressive aphasia (previously semantic dementia), the neural basis for this remains unclear, particularly in light of their well-established hippocampal involvement. We recently investigated the Papez network of memory structures across pathological subtypes of behavioural variant frontot...

Quantification methods employing stable isotope-labeled peptide standards and liquid chromatography–tandem mass spectrometry are increasingly being used to measure enzyme amounts in biologic samples. Isoform concentrations, combined with catalytic information, can be used in absorption, distribution, metabolism, and excretion studies to improve accuracy of in vitro/in vivo predictions. We quant...

Recent guidance on drug-drug interaction (DDI) testing recommends evaluation of circulating metabolites. However, there is little consensus on how to quantitatively predict and/or assess the risk of in vivo DDIs by multiple time-dependent inhibitors (TDIs) including metabolites from in vitro data. Fluoxetine was chosen as the model drug to evaluate the role of TDI metabolites in DDI prediction ...

climate change is one of the most important problems in the present century. so assessing and prediction of future changes is important on water resources and so important for economics and socio-economic consequences. the purpose of this research is assessing the effects of climate change on surface runoff volumes under the scenarios: a1b, a2 and b1 using hadcm3 general circulation model and i...

assessing the potential impacts of 21st-century climate change on species distributions and ecological processes requires climate scenarios with sufficient spatial resolution. in this study we projected future changes in maximum temperature and minimum temperature under cmip3 sres and cmip5 rcps scenarios with two station-based datasets (arazkoseh and nodeh) of the eastern golestan province. ch...