n-3 polyunsaturated fatty acids (PUFAs) are beneficial for numerous models of liver diseases. The probable protective effects of n-3 PUFA against carbon-tetrachloride- (CCl4-) induced acute liver injury were evaluated in a fat-1 transgenic mouse that synthesizes endogenous n-3 from n-6 PUFA. Fat-1 mice and their WT littermates were fed a modified AIN93 diet containing 10% corn oil and were inje...

Carbon tetrachloride (CCl4) is a liquid that colorless, transparent, inflammable, and volatile. Its central carbon atom surrounded by four Cl- atoms. As result, the objective of this effort was to estimate anti-oxidant properties silver nanoparticles (AgNPs) made utilizing aqueous plant extracts from Taraxacum officinale leaves. A green synthesis AgNPs using synergistic extract T. leaves tested...

OBJECTIVES Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. MATERIALS AND METHODS Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7...

The present paper examines the susceptibility to chlordecone (Kepone, CD) and carbon tetrachloride across different ages (35, 45, and 63-days-old) in male and female Sprague-Dawley rats using different lengths of time on a CD diet (10 ppm). The principal findings are that the hepatotoxicity and mortality associated with CD-CCl4 interaction is highly age-dependent for both sexes. There was marke...

Background: Various investigations have established that carbon tetrachloride (CCl4), a clear, colourless, volatile, heavy and nonflammable liquid, causes generation of free radicals in many tissues such as testis. a wide range of side effects such as reproductive toxicity has been observed following the administration of this liquid in experimental animals. Numerous studies have shown that amo...

Capparis spinosa L. (Caper) is known as an aromatic plant, commonly used in Mediterranean diet, possessing numerous antioxidant compounds such as phenols, rutin, tocopherols, carotenoids, and vitamin C in its leaves. Thus, the purpose of the present study was to investigate the effects of Iranian Caper leaves extract on oxidative stress caused by CCl4 in mice liver. In this study, a total numbe...

TGF-β1 is known to inhibit muscle regeneration after muscle injury. However, it is unknown if high systemic levels of TGF-β can affect the muscle regeneration process. In the present study, we demonstrated the effect of a CCl4 intra-peritoneal injection and losartan (an angiotensin II type 1 receptor antagonist) on skeletal muscle (gastrocnemius muscle) injury and regeneration. Male C57BL/6 mic...

Mice ingesting a standard rodent diet supplemented with polybrominated biphenyls (PBBs) were more susceptible to chlorinated hydrocarbon solvent-induced renal and hepatic damage, as well as the lethal effects of CHCl3 and CCl4, than were mice consuming control diet. As little as 0.025 ml/kg CHCl3 caused a significant increase in serum glutamic oxaloacetic transaminase (SGOT) and blood urea nitr...

protective action of ficus carica leaf ethanolic extract (obtained by maceration) was evaluated in an animal model of hepatotoxicity induced by carbon tetrachloride (ccl4). male albino mice were divided into six groups. group i was normal control group; group ii received olive oil (ccl4 solvent), groups iii-vi received ccl4. after inducing hepatic damage, group iii served as control for ccl4; a...