Leila Zeidooni
Department of Pharmacology and Toxicology, Pharmacy School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
[ 1 ] - Prevalence of Symptoms in Patients Poisoned with Iranian Crack in Ahvaz Razi Hospital in 2008-2013
Background: Crack is a strong and smoking form of cocaine, but Iranian crack is different from common crack cocaine, having symptoms and side effects similar to those of heroin. This study was to investigate the prevalence and clinical symptoms in patients poisoned with Iranian crack poisoning hospitalized in Ahvaz Razi Hospital in the years 2008-2013. Methods: In this study, 63 subjects with I...
[ 2 ] - Protective effect of metformin on toxicity of butyric acid and arsenic in isolated liver mitochondria and langerhans islets in male mice: an in vitro study
Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...
[ 3 ] - Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Na...
[ 4 ] - Evaluation the protective effects of doxycycline on acetaminophen-induced hepatotoxicity in mice
Acetaminophen (APAP) toxicity threatens human health due to increased mortality associated with its overdose. Doxycycline (DC) because of its properties such as antioxidant and anti-inflammatory can be a good therapeutic strategy to treat the acute toxicity induced by APAP. Male mice were divided to six groups in two periods of 3 and 24-h as normal saline, APAP 400 mg/kg, DC 100 mg/kg and group...
[ 5 ] - Hydroalcoholic extract of Iranian Caper leaves protects hepatic toxicity by suppressing oxidative stress in mice
Capparis spinosa L. (Caper) is known as an aromatic plant, commonly used in Mediterranean diet, possessing numerous antioxidant compounds such as phenols, rutin, tocopherols, carotenoids, and vitamin C in its leaves. Thus, the purpose of the present study was to investigate the effects of Iranian Caper leaves extract on oxidative stress caused by CCl4 in mice liver. In this study, a total numbe...
[ 6 ] - Evaluation the protective effects of doxycycline on acetaminophen-induced hepatotoxicity in mice
Acetaminophen (APAP) toxicity threatens human health due to increased mortality associated with its overdose. Doxycycline (DC) because of its properties such as antioxidant and anti-inflammatory can be a good therapeutic strategy to treat the acute toxicity induced by APAP. Male mice were divided to six groups in two periods of 3 and 24-h as normal saline, APAP 400 mg/kg, DC 100 mg/kg and group...
[ 7 ] - Mesobuthus eupeus venom induced injury in the colorectal carcinoma cell line (HT29) through altering the mitochondria membrane stability
Objective(s): The purpose of this study was to investigate cytotoxicity and membrane toxicity effects induced by Mesobuthus eupeus venom (MEV) on the HT-29 cell line. Materials and Methods: To determine the in vitro cytotoxicity via MTT assays, HT-29 (as cancer cell line) and Hek-293T (as normal cell) were treated through different conce...
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