BACKGROUND Kulldorff's spatial scan statistic has been one of the most widely used statistical methods for automatic detection of clusters in spatial data. One limitation of this method lies in the fact that it has to rely on scan windows with predefined shapes in the search process, and therefore it cannot detect cluster with arbitrary shapes. We employ a new neighbor-expanding approach and in...

CRISPR-Cas (clustered regularly interspaced short palindromic repeats—CRISPR associated proteins) is a RNA-guided defense immune system that prevents some genetic elements such as plasmids and virus from getting into the bacterial cells. Zymomonas mobilis is an ethanologenic bacterium, which encodes a subtype I-F CRISPR-Cas system containing three CRISPR loci and a far distant cas gene cluster....

A simple multi-residue method was developed for detecting and quantifying 33 analytes from 13 classes of antibiotics (tetracyclines (3), quinolones (7), penicillins (3), ionophore coccidiostats (7), macrolides (3), sulfonamides (1), quinoxalines (2), phenicols (2), lincosamides (1), diaminopyrimidines (1), polypeptides (1), streptogramins (1) and pleuromutilins (1)) in animal feeds. Extraction ...

The organochlorine compounds (OCs) contamination was studied in different tissues of the adult Black Sea turbot (BST) from natural spawning populations of 2008, 2009 and 2013 in the South-Western shelf off Crimea, the Black Sea. Total lipids, six congeners of polychlorinated biphenyl (CB 28, 52, 101, 138, 153, 180) and organochlorine pesticide p,p’DDT including its metabolites p,p’DDE and p,p’D...

Linking CRISs (Current Research Information Systems) and OA (Open Access) Systems brings together systems for managing R&D with systems for providing open access to scholarly publishing – the major visible output of R&D – on the emerging European GRIDs infrastructure. The debate over OA is very active with ‘green’ (institutional repository selfarchiving) and ‘gold’ (author / institution pays pu...

The purpose of this Note is to prove a form of CLT (Theorem 1.4) that is used in Epstein and Seo (2011). More general central limit results and other applications will follow in later drafts. Let S = fB;Ng and K (S) = ffBg; fNg; fB;Ngg the set of nonempty subsets of S. Denote by s1 = (s1; s2; :::) the generic element of S1 and by n (s1) the empirical frequency of the outcome B in the …rst n exp...

BACKGROUND Iron deficiency and poor linear growth are common in infants from deprived socioeconomic backgrounds and may be associated with inadequate complementary feeding (CF) practices. OBJECTIVE We tested the hypothesis that new CF guidelines emphasizing meat as a source of iron and zinc would improve linear growth, iron, and zinc status in infants living in poor socioeconomic circumstance...

The proliferation of CRISPR/Cas9-based methods in Caenorhabditis elegans has enabled efficient genome editing and precise genomic tethering of Cas9 fusion proteins. Experimental designs using CRISPR/Cas9 are currently limited by the need for a protospacer adjacent motif (PAM) in the target with the sequence NGG. Here we report the characterization of two modified Cas9 proteins in C. elegans tha...